Synple Chem AG, Kemptthal, Switzerland; ETH, Zurich, Switzerland.
Prog Med Chem. 2021;60:191-272. doi: 10.1016/bs.pmch.2021.01.003. Epub 2021 Jun 7.
Having always been driven by the need to get new treatments to patients as quickly as possible, drug discovery is a constantly evolving process. This chapter will review how medicinal chemistry was established, how it has changed over the years due to the emergence of new enabling technologies, and how early advances in synthesis, purification and analysis, have provided the foundations upon which the current automated and enabling technologies are built. Looking beyond the established technologies, this chapter will also consider technologies that are now emerging, and their impact on the future of drug discovery and the role of medicinal chemists.
出于尽快将新疗法带给患者的强烈需求，药物研发是一个不断演进的过程。本章将回顾药物化学的建立过程，以及由于新技术的出现而导致的多年来的变化，并探讨合成、纯化和分析方面的早期进展如何为当前自动化和新兴技术奠定了基础。在探讨现有技术之外，本章还将考虑当前新兴的技术及其对药物研发的未来以及药物化学家的作用的影响。
