Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Switzerland.
Mol Aspects Med. 2021 Dec;82:100987. doi: 10.1016/j.mam.2021.100987. Epub 2021 Jun 16.
The molecular machinery of macroautophagy, a catabolic pathway for cytoplasmic constituent degradation in lysosomes, remodels membranes by lipid phosphorylation and conjugation of LC3 and GABARAP proteins. In recent year it has become clear that these membrane modifications also regulate endo- and exocytosis. Here I will discuss recent evidence of how such non-canonical functions of the macroautophagy machinery with its autophagy related gene (atg) products influences infectious viral particle secretion, inflammation, and MHC restricted antigen presentation. Especially LC3-Associated Phagocytosis and ATG supported exocytosis will be high-lighted during immunity and infection.
巨自噬的分子机制是溶酶体中细胞质成分降解的分解代谢途径，通过脂质磷酸化和 LC3 和 GABARAP 蛋白的缀合重塑膜。近年来，人们已经清楚地认识到这些膜修饰还调节内吞作用和胞吐作用。在这里，我将讨论最近的证据，说明巨自噬机制及其自噬相关基因 (atg) 产物的这种非典型功能如何影响传染性病毒粒子的分泌、炎症和 MHC 受限的抗原呈递。在免疫和感染过程中，将特别强调 LC3 相关吞噬作用和 ATG 支持的胞吐作用。
