Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Surgery, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.
Crit Rev Oncol Hematol. 2021 Jul;163:103398. doi: 10.1016/j.critrevonc.2021.103398. Epub 2021 Jun 18.
Inflammation has been well-established as a hallmark of colorectal cancer (CRC). Interleukin-1 alpha (IL-1α) is one of the primary inflammatory mediators driving the pathogenesis of inflammation-associated CRC. This systematic review presents the roles of IL-1α in the pathogenesis of the disease. Bibliographic databases PubMed, Science Direct, Scopus and Web of Science were systematically searched for articles that addresses the relationship between IL-1α and colorectal cancer. We highlighted various mechanisms by which IL-1α promotes the pathogenesis of CRC including enhancement of angiogenesis, metastasis, resistance to therapy, and inhibition of tumour suppressive genes. We also discussed the potential mechanisms by which IL-1α expression is induced or secreted in various studies. Beyond these, the systematic review also highlights several potential therapeutic strategies which should be further explored in the future; to target IL-1α and/or its associated pathways; paving our way in finding effective treatments for CRC patients.
炎症已被明确为结直肠癌（CRC）的一个标志。白细胞介素-1α（IL-1α）是驱动炎症相关 CRC 发病机制的主要炎症介质之一。本系统评价介绍了 IL-1α 在疾病发病机制中的作用。通过系统搜索 PubMed、Science Direct、Scopus 和 Web of Science 等文献数据库，查找了探讨 IL-1α 与结直肠癌之间关系的文章。我们强调了 IL-1α 促进 CRC 发病机制的各种机制，包括促进血管生成、转移、对治疗的耐药性和抑制肿瘤抑制基因。我们还讨论了在各种研究中诱导或分泌 IL-1α 的潜在机制。除此之外，系统评价还强调了几种有前途的治疗策略，这些策略在未来应该进一步探索；以靶向 IL-1α 和/或其相关途径为目标，为寻找 CRC 患者的有效治疗方法铺平道路。
