Artemisinin Research Center and the Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Med Res Rev. 2021 Nov;41(6):3156-3181. doi: 10.1002/med.21837. Epub 2021 Jun 20.
Artemisinins are a family of sesquiterpene lactones originally derived from the sweet wormwood (Artemisia annua). Beyond their well-characterized role as frontline antimalarial drugs, artemisinins have also received increased attention for other potential pharmaceutical effects, which include antiviral, antiparsitic, antifungal, anti-inflammatory, and anticancer activities. With concerted efforts in further preclinical and clinical studies, artemisinin-based drugs have the potential to be viable treatments for a great variety of human diseases. Here, we provide a comprehensive update on recent reports of pharmacological actions and applications of artemisinins outside of their better-known antimalarial role and highlight their potential therapeutic viability for various diseases.
青蒿素是一类倍半萜内酯化合物，最初来源于青蒿（Artemisia annua）。除了作为一线抗疟药物的特征作用外，青蒿素在其他潜在的药物作用方面也受到了越来越多的关注，包括抗病毒、抗寄生虫、抗真菌、抗炎和抗癌作用。通过进一步的临床前和临床研究的协同努力，基于青蒿素的药物有可能成为治疗各种人类疾病的可行方法。在这里，我们提供了关于青蒿素除了更好地治疗疟疾作用之外的药理学作用和应用的最新报告的综合更新，并强调了它们在各种疾病治疗中的潜在治疗可行性。
