College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, P. R. China.
Wuhan Humanwell Pharmaceutical Co. Ltd., Wuhan, 430206, P. R. China.
Adv Biol (Weinh). 2023 Aug;7(8):e2300086. doi: 10.1002/adbi.202300086. Epub 2023 May 13.
Artemisinin (ART) and its derivatives have great therapeutical utility as antimalarials and can be repurposed for other indications, such as viral infections, autoimmune diseases, and cancer. This review presents a comprehensive overview of the therapeutic effects of ART-based drugs, beyond their antimalarial effects. This review also summarizes the information on their repurposing in other pathologies, with the hope that it will guide the future optimization of the use of ART-based drugs and of the treatment strategies for the listed diseases. By reviewing related literature, ART extraction and structure as well as the synthesis and structure of its derivatives are presented. Subsequently, the traditional roles of ART and its derivatives against malaria are reviewed, including antimalarial mechanism and occurrence of antimalarial resistance. Finally, the potential of ART and its derivatives to be repurposed for the treatment of other diseases are summarized. The great repurposing potential of ART and its derivatives may be useful for the control of emerging diseases with corresponding pathologies, and future research should be directed toward the synthesis of more effective derivatives or better combinations.
青蒿素（ART）及其衍生物作为抗疟药具有很大的治疗作用，并且可以重新用于其他适应症，如病毒感染、自身免疫性疾病和癌症。本综述全面介绍了基于 ART 的药物的治疗效果，超越了其抗疟作用。本综述还总结了它们在其他病理情况下的重新应用信息，希望能为未来基于 ART 的药物的使用优化和列出疾病的治疗策略提供指导。通过回顾相关文献，介绍了 ART 的提取和结构以及其衍生物的合成和结构。随后，综述了 ART 及其衍生物对抗疟疾的传统作用，包括抗疟机制和抗疟耐药性的发生。最后，总结了 ART 及其衍生物在治疗其他疾病方面的潜在用途。ART 及其衍生物的巨大再利用潜力可能对控制具有相应病理的新发疾病有用，未来的研究应致力于合成更有效的衍生物或更好的组合。
