利用多维类器官模型构建结直肠癌。
Modeling colorectal cancers using multidimensional organoids.
机构信息
Department of Pathology, University of California, San Diego, CA, United States.
Department of Cellular and Molecular Medicine, University of California, San Diego, CA, United States.
出版信息
Adv Cancer Res. 2021;151:345-383. doi: 10.1016/bs.acr.2021.02.005. Epub 2021 Mar 26.
Organoids have revolutionized cancer research as highly adaptable models that enable an array of experimental techniques to interrogate tissue morphology and function. Because they preserve the genetic, phenotypic, and behavioral traits of their source tissue, organoids have gained traction as the most relevant models for drug discovery, tracking therapeutic response and for personalized medicine. As organoids are indisputably becoming a mainstay of cancer research, this review specifically addresses how colon-derived organoids can be perfected as multidimensional, scalable, reproducible models of healthy, pre-neoplastic and neoplastic conditions of the colon and for use in high-throughput "Phase-0" human clinical trials-in-a-dish.
类器官已经彻底改变了癌症研究，因为它们是高度可适应的模型，能够利用一系列实验技术来研究组织形态和功能。由于类器官保留了其来源组织的遗传、表型和行为特征，因此它们作为药物发现、跟踪治疗反应和个性化医疗的最相关模型而受到关注。随着类器官无疑成为癌症研究的主要支柱，本综述特别讨论了如何将结肠来源的类器官完善为健康、癌前和肿瘤状态的结肠的多维、可扩展、可重复的模型，并用于高通量“0 期”人体临床试验。
Zotero 插件