Lee Jong Seok, Park Sun Cheol, Kim Sang Dong
Division of Vascular and Transplant Surgery, Department of Surgery, Incheon St. Mary's Hospital, The Catholic University of Korea, Incheon, 21431, South Korea.
Division of Vascular and Transplant Surgery, Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, South Korea.
Asian J Surg. 2022 Jan;45(1):307-314. doi: 10.1016/j.asjsur.2021.05.046. Epub 2021 Jun 17.
Metabolic syndrome (MetS) is a cluster of metabolic abnormalities strongly associated with risks of cardiovascular diseases. However, a relationship between MetS and aneurysmal disease as compared with occlusive disease has not been confirmed. Therefore, correlations of MetS and abdominal aortic aneurysm (AAA) were evaluated.
Between March 2011 and February 2020, 354 patients diagnosed with AAA were enrolled and divided into the MetS (n = 164) and the no-MetS (n = 190) groups. Individual components of MetS, characteristics of AAA, rupture rate, and survival rate were evaluated for both groups. Additionally, correlations between MetS and AAA were evaluated with focusing on effects of diabetes mellitus (DM).
The size of AAA was significantly larger in the MetS group compared with the no-MetS group (P < 0.05). The rupture rate was significantly higher in the MetS group compared with the no-MetS group (P < 0.05) and the survival rate was significantly higher in the no-MetS group (P < 0.05). In terms of DM, the size of AAA was significantly larger in the no-DM group compared with the DM group (P < 0.05). MetS was significantly more prevalent in the DM group compared with the no-DM group (P < 0.05). Finally, the rupture and survival rates were not statistically different between the DM and the no-DM groups (P > 0.05).
Although larger prospective studies are necessary, we suggest that MetS proportionally aggravates the status of AAA and survival rate. Therefore, surveillance for MetS and individual components may help to restrict the expansion of AAA.
代谢综合征（MetS）是一组与心血管疾病风险密切相关的代谢异常。然而，与闭塞性疾病相比，MetS与动脉瘤性疾病之间的关系尚未得到证实。因此，评估了MetS与腹主动脉瘤（AAA）之间的相关性。
在2011年3月至2020年2月期间，纳入354例诊断为AAA的患者，并将其分为MetS组（n = 164）和非MetS组（n = 190）。对两组患者的MetS个体成分、AAA特征、破裂率和生存率进行评估。此外，重点关注糖尿病（DM）的影响，评估MetS与AAA之间的相关性。
与非MetS组相比，MetS组的AAA尺寸明显更大（P < 0.05）。与非MetS组相比，MetS组的破裂率明显更高（P < 0.05），而非MetS组的生存率明显更高（P < 0.05）。就DM而言，非DM组的AAA尺寸明显大于DM组（P < 0.05）。与非DM组相比，DM组中MetS的患病率明显更高（P < 0.05）。最后，DM组和非DM组之间的破裂率和生存率无统计学差异（P > 0.05）。
尽管需要更大规模的前瞻性研究，但我们认为MetS会按比例加重AAA的病情和生存率。因此，对MetS及其个体成分进行监测可能有助于限制AAA的扩张。
