Cho In Young, Koo Hye Yeon, Han Kyungdo, Lee Kyu Na, Cho Mihee, Jin Sang-Man, Cho Yang Hyun, Lee Jun Ho, Park Yang-Jin, Shin Dong Wook
Department of Family Medicine, Kangbuk Samsung Hospital Sungkyunwan University, School of Medicine, Seoul, South Korea; Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Atherosclerosis. 2023 Dec;386:117329. doi: 10.1016/j.atherosclerosis.2023.117329. Epub 2023 Oct 9.
The association between metabolic syndrome (MetS) and abdominal aortic aneurysm (AAA) remains unclear. We investigated the potential association between AAA and MetS and its components in a large population-based cohort.
We used the Korean National Health Insurance Service database including 4,162,640 participants aged ≥50 years who received a routine health examination in 2009. Cox proportional hazards models were used to analyze the association between MetS and its components (elevated waist circumference, blood pressure, glucose, triglycerides, and reduced high-density lipoprotein cholesterol [HDL-C]) with AAA incidence, with adjustment for confounders.
During a median 9.4 years of follow-up, 18,160 participants developed incident AAA. MetS was associated with an increased risk of AAA compared to the non-MetS group (adjusted hazard ratio [aHR], 1.38; 95% confidence interval [CI], 1.34-1.43). Among the individual components, elevated waist circumference, blood pressure, triglycerides, and reduced HDL-C were associated with increased AAA risk, while elevated glucose alone was associated with reduced AAA risk (aHR, 0.85; 95% CI, 0.82-0.87). AAA risk also increased linearly with the increasing number of MetS components, with the highest risk found in the presence of all 5 components (aHR, 1.98, 95% CI, 1.83-2.15).
MetS and its individual components, with the exclusion of elevated glucose, were associated with higher risk of AAA. Further studies are warranted to elucidate the association between MetS and AAA.
代谢综合征（MetS）与腹主动脉瘤（AAA）之间的关联仍不明确。我们在一个基于人群的大型队列中研究了AAA与MetS及其组成成分之间的潜在关联。
我们使用了韩国国民健康保险服务数据库，该数据库包含2009年接受常规健康检查的4162640名年龄≥50岁的参与者。采用Cox比例风险模型分析MetS及其组成成分（腰围增加、血压升高、血糖升高、甘油三酯升高和高密度脂蛋白胆固醇[HDL-C]降低）与AAA发病率之间的关联，并对混杂因素进行了调整。
在中位9.4年的随访期间，18160名参与者发生了新发AAA。与非MetS组相比，MetS与AAA风险增加相关（调整后风险比[aHR]，1.38；95%置信区间[CI]，1.34 - 1.43）。在各个组成成分中，腰围增加、血压升高、甘油三酯升高和HDL-C降低与AAA风险增加相关，而仅血糖升高与AAA风险降低相关（aHR，0.85；95% CI，0.82 - 0.87）。AAA风险也随着MetS组成成分数量的增加而呈线性增加，在存在所有5个组成成分时风险最高（aHR，1.98，95% CI，1.83 - 2.15）。
除血糖升高外，MetS及其各个组成成分与AAA风险较高相关。有必要进行进一步研究以阐明MetS与AAA之间的关联。
