Milligan K A, Mowbray M J, Mulrooney L, Standen P J
Mansfield and District General Hospital, Nottinghamshire.
Anaesthesia. 1988 Jul;43(7):563-4. doi: 10.1111/j.1365-2044.1988.tb06688.x.
A randomised double-blind study was conducted to compare the influence on postoperative pain of equal volumes of one of two concentrations of bupivacaine (0.25%, 0.5%), or saline 0.9%, injected into the knee joint after arthroscopy. The results showed that intra-articular bupivacaine had no significant analgesic effect in either concentration. Plasma bupivacaine concentrations were measured 20 minutes after injection in order to determine the extent of systemic absorption.
进行了一项随机双盲研究，以比较关节镜检查后向膝关节注射等体积的两种浓度（0.25%、0.5%）布比卡因之一或0.9%生理盐水对术后疼痛的影响。结果表明，两种浓度的关节内布比卡因均无显著镇痛效果。注射后20分钟测量血浆布比卡因浓度，以确定全身吸收程度。
