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1
Endoscopic endonasal surgery for Clival Chordomas - a single institution experience and short term outcomes.经鼻内镜手术治疗斜坡脊索瘤——单中心经验及短期疗效
Br J Neurosurg. 2019 Aug;33(4):388-393. doi: 10.1080/02688697.2019.1567683. Epub 2019 Feb 11.
2
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Ann Otol Rhinol Laryngol. 2019 Mar;128(3):208-214. doi: 10.1177/0003489418816723. Epub 2018 Dec 10.
3
A comprehensive review of the clivus: anatomy, embryology, variants, pathology, and surgical approaches.斜坡的全面综述:解剖学、胚胎学、变异、病理学及手术入路
Childs Nerv Syst. 2018 Aug;34(8):1451-1458. doi: 10.1007/s00381-018-3875-x. Epub 2018 Jun 28.
4
Clival Chordoma: Case Report and Review of Recent Developments in Surgical and Adjuvant Treatments.斜坡脊索瘤:病例报告及手术与辅助治疗的最新进展综述
Pol J Radiol. 2017 Nov 17;82:670-675. doi: 10.12659/PJR.902008. eCollection 2017.
5
A historical recount of chordoma.脊索瘤的历史回顾。
J Neurosurg Spine. 2018 Apr;28(4):422-428. doi: 10.3171/2017.7.SPINE17668. Epub 2018 Feb 2.
6
Recent advances in understanding and managing chordomas.脊索瘤的认识与治疗新进展
F1000Res. 2016 Dec 22;5:2902. doi: 10.12688/f1000research.9499.1. eCollection 2016.
7
Three-dimensional endoscopy in transnasal transsphenoidal approach to clival chordomas.经鼻蝶入路治疗斜坡脊索瘤的三维内镜技术
Head Neck. 2016 Apr;38 Suppl 1:E1814-9. doi: 10.1002/hed.24324. Epub 2015 Dec 24.
8
Chordoma: an update on the pathophysiology and molecular mechanisms.脊索瘤:病理生理学与分子机制的最新进展
Curr Rev Musculoskelet Med. 2015 Dec;8(4):344-52. doi: 10.1007/s12178-015-9311-x.
9
Contemporary management of clival chordomas.斜坡脊索瘤的现代治疗
Curr Opin Otolaryngol Head Neck Surg. 2015 Apr;23(2):153-61. doi: 10.1097/MOO.0000000000000140.
10
A virtual reality model of the clivus and surgical simulation via transoral or transnasal route.斜坡的虚拟现实模型及经口或经鼻途径的手术模拟
Int J Clin Exp Med. 2014 Oct 15;7(10):3270-9. eCollection 2014.

经鼻内镜入路在斜坡脊索瘤手术中的应用:病例系列

Endoscopic Endonasal Approach in Clival Chordoma Surgery: Case Series.

作者信息

Ngu Chien Ying Vincent, Tang Ing Ping, Ng Boon Han Kevin, Wong Albert S I I Hieng, Liew Donald Ngian San

机构信息

Department of Otorhinolaryngology, Sarawak General Hospital, Otorhinolaryngology - Head and Neck Surgery Department, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Department of Otorhinolaryngology, Sarawak General Hospital, Department of ORL-HNS, Faculty of Medicine and Health Sciences, University Malaysia Sarawak, 94300 Kota Samarahan, Sarawak Malaysia.

出版信息

Indian J Otolaryngol Head Neck Surg. 2021 Jun;73(2):226-232. doi: 10.1007/s12070-021-02455-6. Epub 2021 Feb 23.

DOI:10.1007/s12070-021-02455-6
PMID:34150596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8163901/
Abstract

Chordomas are rare and slow-growing locally destructive bone tumors that can develop in the craniospinal axis. It is commonly found in the sacrococcygeal region whereas only 25-35% are found in the clival region. Headache with neurological deficits are the most common clinical presentations. Complete surgical resection either via open or endoscopic endonasal approaches are the main mode of treatment. Here, we report a series of 5 cases of clival chordomas which was managed via endoscopic endonasal approaches in our center. A retrospective analysis of patients who had undergone endoscopic endonasal resection of clival chordoma in Sarawak General Hospital from 2014 to 2018. A total of 5 cases were operated on endoscopically via a combine effort of both the otorhinolaryngology team and the neurosurgical team during the study period from year 2013 to 2018. From our patient, 2 were female and 3 were male patients. The main clinical presentation was headache, squinting of eye and nasopharyngeal fullness. All our patient had endoscopic endonasal debulking of clival tumor done, with average of hospital stay from 9 - 23 days. Pos-operatively, patients were discharged back well. Endoscopic endonasal resection of clival chordomas gives good surgical resection results with low morbidity rates and therefore can be considered as a surgical option in centers where the surgical specialties are available.

摘要

脊索瘤是一种罕见的、生长缓慢的局部侵袭性骨肿瘤,可发生于颅脊柱轴。它常见于骶尾区域,而仅25% - 35%发生于斜坡区域。伴有神经功能缺损的头痛是最常见的临床表现。通过开放手术或内镜经鼻入路进行完全手术切除是主要的治疗方式。在此,我们报告了一系列5例斜坡脊索瘤病例,这些病例在我们中心通过内镜经鼻入路进行治疗。对2014年至2018年在砂拉越总医院接受内镜经鼻切除斜坡脊索瘤的患者进行回顾性分析。在2013年至2018年的研究期间,共有5例患者通过耳鼻喉科团队和神经外科团队的共同努力接受了内镜手术。在我们的患者中,2例为女性,3例为男性。主要临床表现为头痛、斜视和鼻咽部饱满。我们所有患者均接受了内镜经鼻切除斜坡肿瘤,平均住院时间为9 - 23天。术后,患者康复出院。内镜经鼻切除斜坡脊索瘤手术切除效果良好,发病率低,因此在具备手术专科的中心可被视为一种手术选择。