Institute of Health Behaviors and Community Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan.
Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
Clin Toxicol (Phila). 2022 Jan;60(1):131-135. doi: 10.1080/15563650.2021.1937642. Epub 2021 Jun 21.
Pesticide ingestion is a leading method for suicide worldwide. Paraquat is a highly lethal herbicide when ingested. We assessed the impact of the first-stage ban on the import and production of paraquat (from February 2018) on suicides by pesticide poisoning in Taiwan.
Suicide data by method (pesticide vs. non-pesticide), pesticide (paraquat vs. non-paraquat), and area/sex/age were extracted from the national cause-of-death data files (2011-2019). Negative binomial regression was used to estimate changes in suicide rates in 2019, compared to the expected rates based on pre-ban linear trends (2011-2017).
The paraquat ban was followed by an estimated 37% (rate ratio [RR] = 0.63, 95% confidence interval [CI] 0.54-0.74) reduction in pesticide suicide rate (190 [95% CI 116-277] fewer suicides) in 2019, mainly due to a 58% (RR = 0.42, 95% CI 0.33-0.54) reduction in paraquat suicides (145 [95% CI 92-213] fewer suicides). Larger absolute reductions in pesticide suicides were found in rural areas, males, and the elderly (aged 65+ years) than their counterparts. Except for a 10% (95% CI 3-18%) reduction in overall suicide rates in the elderly, there was no statistical evidence for a change in non-pesticide and overall (all-method) suicides.
The ban on the import and production of paraquat was followed by a fall in whole-population pesticide and paraquat suicides and elderly suicides in Taiwan.
在全球范围内,农药摄入是自杀的主要手段。百草枯是一种剧毒除草剂,摄入后会致命。我们评估了 2018 年 2 月第一阶段禁止进口和生产百草枯对台湾地区农药中毒自杀的影响。
从国家死因数据文件(2011-2019 年)中提取了按自杀方法(农药与非农药)、农药(百草枯与非百草枯)和地区/性别/年龄分类的自杀数据。使用负二项回归比较了 2019 年与 2011-2017 年线性趋势预测的自杀率变化。
百草枯禁令实施后,2019 年农药自杀率估计下降了 37%(RR=0.63,95%CI 0.54-0.74)(减少 190 例自杀,95%CI 116-277),主要是由于百草枯自杀减少了 58%(RR=0.42,95%CI 0.33-0.54)(减少 145 例自杀,95%CI 92-213)。农村地区、男性和 65 岁以上老年人的农药自杀绝对减少量更大。除了老年人的总体自杀率下降了 10%(95%CI 3-18%)外,没有证据表明非农药和全人群(所有方法)自杀有变化。
台湾地区禁止进口和生产百草枯后,全人群农药和百草枯自杀以及老年人自杀人数下降。