Knipe Duleeka W, Chang Shu-Sen, Dawson Andrew, Eddleston Michael, Konradsen Flemming, Metcalfe Chris, Gunnell David
South Asian Clinical Toxicology Research Collaboration (SACTRC), Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol, United Kingdom.
PLoS One. 2017 Mar 6;12(3):e0172893. doi: 10.1371/journal.pone.0172893. eCollection 2017.
To investigate the effect of 3-year phased bans of the pesticides dimethoate and fenthion in 2008-2010, and paraquat in 2009-2011, on suicide mortality in Sri Lanka.
Age-standardised overall, sex-specific, and method-specific suicide rates were calculated using Sri Lankan police data (1989-2015). Using negative binomial regression models, we estimated the change in the rate and number of suicide deaths in post-ban years (2011-15) compared to those expected based on pre-ban trends (2001-10).
Overall suicide mortality dropped by 21% between 2011 and 2015, from 18.3 to 14.3 per 100,000. The decline in pesticide suicides during this same period was larger than for overall suicides: from 8.5 to 4.2 per 100,000, a 50% reduction. This was accompanied by a smaller concurrent rise in non-pesticide suicide mortality with a 2% increase (9.9 to 10.1 per 100,000). In 2015, the ratio between the observed and expected pesticide suicide rates was 0.49 (95% confidence interval [CI] 0.40, 0.62), corresponding to an estimated 937 (95% CI 574, 1389) fewer pesticide suicides than expected from pre-ban suicide rates. Findings were similar in sensitivity analyses using 2008 or 2012 as commencement of the post intervention period.
Bans of paraquat, dimethoate and fenthion in Sri Lanka were associated with a reduction in pesticide suicide mortality and in overall suicide mortality despite a small rise in other methods. This study provides further evidence for the effectiveness of pesticide regulation in limiting the availability of highly hazardous pesticides and thereby reducing the number of global suicides.
调查2008 - 2010年对乐果和倍硫磷这两种农药实施的为期3年的分阶段禁令,以及2009 - 2011年对百草枯实施的禁令对斯里兰卡自杀死亡率的影响。
利用斯里兰卡警方数据(1989 - 2015年)计算年龄标准化的总体自杀率、按性别划分的自杀率以及按自杀方法划分的自杀率。使用负二项回归模型,我们估计了禁令实施后年份(2011 - 15年)与基于禁令实施前趋势(2001 - 10年)预期的自杀死亡人数和自杀率的变化。
2011年至2015年期间,总体自杀死亡率下降了21%,从每10万人18.3例降至14.3例。同期农药自杀率的下降幅度大于总体自杀率的下降幅度:从每10万人8.5例降至4.2例,下降了50%。与此同时,非农药自杀死亡率有较小幅度的上升,上升了2%(从每10万人9.9例升至10.1例)。2015年,观察到的农药自杀率与预期农药自杀率之比为0.49(95%置信区间[CI] 0.40, 0.62),这意味着与禁令实施前的自杀率相比,农药自杀死亡人数估计减少了937例(95% CI 574, 1389)。在以2008年或2012年作为干预后时期开始时间的敏感性分析中,研究结果相似。
斯里兰卡对百草枯、乐果和倍硫磷的禁令与农药自杀死亡率和总体自杀死亡率的降低有关,尽管其他自杀方法略有上升。本研究为农药监管在限制高危险农药的可及性从而减少全球自杀人数方面的有效性提供了进一步证据。