Wong J H, Euhus D M, Morton D L
Division of Surgical Oncology, John Wayne Cancer Clinic, UCLA School of Medicine 90024.
Arch Surg. 1988 Sep;123(9):1091-5. doi: 10.1001/archsurg.1988.01400330067010.
From 1971 through December 1986, the courses of 47 patients who underwent thoracotomy for pulmonary metastases from melanoma were retrospectively reviewed to determine the efficacy of this approach in the management of selected patients with melanoma. The overall five-year survival rate was 25% (median survival, 19 months). Thirty-eight patients were free of disease following thoracotomy. These patients fared significantly better than those who had residual disease following thoracotomy, with a five-year survival rate of 31% (median survival, 24 months) compared with 0% (median survival, six months). Survival was not influenced by the addition of adjuvant therapy or duration of time before the development of metastases (less than 12 months vs greater than or equal to 12 months). In selected patients with melanoma metastatic to the lung, thoracotomy with complete excision of the metastatic deposits results in improved survival and should be considered the treatment of choice.
从1971年至1986年12月，对47例因黑色素瘤肺转移而接受开胸手术的患者病程进行回顾性分析，以确定该方法对特定黑色素瘤患者的治疗效果。总体五年生存率为25%（中位生存期为19个月）。38例患者开胸手术后无疾病。这些患者的预后明显好于开胸手术后有残留疾病的患者，五年生存率为31%（中位生存期为24个月），而后者为0%（中位生存期为6个月）。辅助治疗的添加或转移发生前的时间长短（少于12个月与大于或等于12个月）对生存率无影响。对于选定的黑色素瘤肺转移患者，完整切除转移灶的开胸手术可提高生存率，应被视为首选治疗方法。
