Mathisen D J, Flye M W, Peabody J
Ann Thorac Surg. 1979 Apr;27(4):295-9. doi: 10.1016/s0003-4975(10)63302-4.
Thirty-three patients over a 21-year period underwent thoracotomy for resection of suspected pulmonary metastases from malignant melanoma. Eleven patients were found to have nonmalignant disease (Group 1); 10 were found to have unresectable disease (Group 2); and 12 were rendered disease-free (Group 3). Of the patients found to have melanoma, 20 of 22 received post-operative chemotherapy. The median survival of the patients in Group 2 was 10.5 months (3 to 20 months); in Group 3 it was 12 months (3 to 35 months). There were no 5-year survivors. No factors distinguished the three groups preoperatively. Surgical resection still offers the greatest chance for long-term survival, based on reports of patients in the literature who have survived longer than 5 years following resection of pulmonary metastases from melanoma. Thoracotomy is especially useful for staging purposes in those patients found to have no metastatic disease.
在21年的时间里，33例患者因疑似恶性黑色素瘤肺转移而接受了开胸手术切除。11例患者被发现患有非恶性疾病（第1组）；10例被发现患有无法切除的疾病（第2组）；12例实现了无病状态（第3组）。在被发现患有黑色素瘤的患者中，22例中有20例接受了术后化疗。第2组患者的中位生存期为10.5个月（3至20个月）；第3组为12个月（3至35个月）。没有5年生存者。术前没有因素能区分这三组。根据文献中关于黑色素瘤肺转移切除术后存活超过5年的患者报告，手术切除仍然提供了最大的长期生存机会。开胸手术对于那些被发现没有转移性疾病的患者进行分期尤其有用。
