University of Pretoria, Pretoria, Gauteng, South Africa.
University of KwaZulu-Natal, Pietermaritzburg, KwaZulu-Natal, South Africa.
Qual Life Res. 2022 Jan;31(1):171-184. doi: 10.1007/s11136-021-02898-y. Epub 2021 Jun 22.
HRQOL in transplant candidates and recipients who are also infected with HIV and are awaiting a kidney, or have received one from a HIV-positive donor, has not been previously investigated.
The HRQOL of 47 HIV-positive kidney transplant candidates and 21 recipients from HIV-positive donors was evaluated using the Short Form-36 (SF-36) and face to face interviews at baseline and at 6 months. The correlation between SF-36 scores and sociodemographic, clinical and nutritional factors was determined.
68 patients completed the SF-36 at baseline and 6 months. Transplant candidates: transplant candidates had lower HRQOL than recipients. The main mental stressors were income, employment and waiting for a donor. Physical health complaints were body pain (BP) and fatigue. Pre-albumin and BMI was positively correlated with general health at baseline (r = 0.401, p = 0.031 and r = 0.338, p = 0.025). Besides a positive association with role physical (RP) and BP, albumin was associated with overall physical composite score (PCS) (r = 0.329, p = 0.024) at 6 months. Transplant recipients: Transplant recipients had high HRQOL scores in all domains. PCS was 53.8 ± 10.0 and 56.6 ± 6.5 at baseline and 6 months respectively. MCS was 51.3 ± 11.5 and 54.2 ± 8.5 at baseline and 6 months respectively. Albumin correlated positively with PCS (r = 0.464, p = 0.034) at 6 months and role emotional (RE) (r = 0.492, p = 0.024). Higher pre-albumin was associated with better RE and RP abilities and MCS (r = 0.495, p = 0.034). MAMC was associated with four domains of physical health and strongly correlated with PCS (r = 0.821, p = 0.000).
Strategies to improve HRQOL include ongoing social support, assistance with employment issues and optimising nutritional status.
在等待肾移植或已接受 HIV 阳性供体肾移植的移植候选者和受者中，同时感染 HIV 的人群的生活质量（HRQOL）尚未得到研究。
使用 36 项简短健康调查问卷（SF-36）和面对面访谈，评估 47 名 HIV 阳性肾移植候选者和 21 名 HIV 阳性供体肾移植受者的 HRQOL。在基线和 6 个月时，确定 SF-36 评分与社会人口统计学、临床和营养因素之间的相关性。
68 例患者在基线和 6 个月时完成了 SF-36。移植候选者：与受者相比，移植候选者的 HRQOL 较低。主要的精神压力源是收入、就业和等待供体。身体不适主要是身体疼痛（BP）和疲劳。前白蛋白和 BMI 与基线时的总体健康呈正相关（r=0.401，p=0.031 和 r=0.338，p=0.025）。除了与身体角色（RP）和 BP 呈正相关外，白蛋白与 6 个月时的总体身体综合评分（PCS）相关（r=0.329，p=0.024）。移植受者：移植受者在所有领域的 HRQOL 评分均较高。6 个月时 PCS 分别为 53.8±10.0 和 56.6±6.5，MCS 分别为 51.3±11.5 和 54.2±8.5。白蛋白与 6 个月时的 PCS（r=0.464，p=0.034）和角色情感（RE）（r=0.492，p=0.024）呈正相关。较高的前白蛋白与更好的 RE 和 RP 能力和 MCS 相关（r=0.495，p=0.034）。MAMC 与四个身体领域相关，并与 PCS 密切相关（r=0.821，p=0.000）。
提高 HRQOL 的策略包括持续的社会支持、就业问题援助和优化营养状况。
