Department of Public Health, Faculty of Medicine and Health Sciences, An-Najah National University, Ramallah, Palestine.
Palestine Medical Complex, Ministry of Health, Ramallah, Palestine.
BMC Nephrol. 2021 Jun 3;22(1):210. doi: 10.1186/s12882-021-02412-z.
Health related quality of life (HRQOL) is an important indicator of medical treatment and is a strong predictor of disability and mortality. The literature has shown mixed evidence about whether kidney transplantation improves HRQOL compared with other renal replacement modalities. The aim of this study was to compare the HRQOL in kidney transplant recipients (KTRs) and hemodialysis (HD) patients.
A cross-sectional study of 100 KTRs and 272 HD patients from two central kidney units in the West Bank, Palestine. The HRQOL was assessed using the Short Form-36 Health Survey. Multivariable linear regression was used to estimate differences in mean HRQOL scores between KTRs and HD patients.
As compared to HD patients, KTRs had higher clinically important HRQOL in main domains and subscales of the SF-36 including physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, mental health, ranging between 15.5 for social functioning (95% Confidence Interval (CI) 10.1, 20.7) to 32.6 for general health (95% CI 24.0, 41.1).
We found that KTRs have better HRQOL than HD patients in physical and mental components of the SF-36 scale including physical functioning, role-physical, bodily pain, general health, vitality, social functioning, role-emotional, and mental health. Further longitudinal research comparing HRQOL among KTRs and the general population may identify key modifiable factors associated with lower HRQOL among KTRs that are amenable to intervention.
健康相关生活质量(HRQOL)是医疗的重要指标,也是残疾和死亡的强有力预测因素。文献表明,与其他肾脏替代方式相比,肾移植是否能改善 HRQOL 的证据存在差异。本研究旨在比较肾移植受者(KTR)和血液透析(HD)患者的 HRQOL。
这是一项在巴勒斯坦西岸两个中心肾脏单位的 100 名 KTR 和 272 名 HD 患者中进行的横断面研究。使用简明健康调查问卷(SF-36)评估 HRQOL。多变量线性回归用于估计 KTR 和 HD 患者之间平均 HRQOL 评分的差异。
与 HD 患者相比,KTR 在 SF-36 的主要领域和子量表中具有更高的临床重要 HRQOL,包括生理功能、生理角色、身体疼痛、总体健康、活力、社会功能、情绪角色、心理健康,范围从社交功能的 15.5(95%置信区间(CI)10.1,20.7)到总体健康的 32.6(95%CI 24.0,41.1)。
我们发现 KTR 在 SF-36 量表的身体和心理成分方面具有比 HD 患者更好的 HRQOL,包括生理功能、生理角色、身体疼痛、总体健康、活力、社会功能、情绪角色和心理健康。进一步对 KTR 和一般人群之间 HRQOL 进行纵向研究可能会确定与 KTR 较低 HRQOL 相关的关键可改变因素,这些因素可以通过干预来解决。