技术说明:使用基于特征的损失和单周期学习进行放射治疗的剂量预测。

Technical Note: Dose prediction for radiation therapy using feature-based losses and One Cycle Learning.

作者信息

Zimmermann Lukas, Faustmann Erik, Ramsl Christian, Georg Dietmar, Heilemann Gerd

机构信息

Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria.

Technical University of Vienna, Vienna, Austria.

出版信息

Med Phys. 2021 Sep;48(9):5562-5566. doi: 10.1002/mp.14774. Epub 2021 Jun 22.

Abstract

PURPOSE

To present the technical details of the runner-up model in the open knowledge-based planning (OpenKBP) challenge for the dose-volume histogram (DVH) stream. The model was designed to ensure simple and reproducible training, without the necessity of costly advanced generative adversarial network (GAN) techniques.

METHODS

The model was developed based on the OpenKBP challenge dataset, consisting of 200 and 40 head-and-neck patients for training and validation, respectively. The final model is a U-Net with additional ResNet blocks between up- and down convolutions. The results were obtained by training the model with AdamW with the One Cycle scheduler. The loss function is a combination of the L1 loss with a feature loss, which uses a pretrained video classifier as a feature extractor. The performance was evaluated on another 100 patients in the OpenKBP test dataset. The DVH metrics of the test data were evaluated, where , and were calculated for the organs at risk (OARs) and , , and were computed for the target structures. DVH metric differences between predicted and true dose are reported in percentage.

RESULTS

The model achieved 2nd and 4th place in the DVH and dose stream of the OpenKBP challenge, respectively. The dose and DVH score were 2.62 ± 1.10 and 1.52 ± 1.06, respectively. Mean dose differences for the different structures and DVH parameters were within ±1%.

CONCLUSION

This straightforward approach produced excellent results. It incorporated One Cycle Learning, ResNet, and feature-based losses, which are common computer vision techniques.

摘要

目的

介绍剂量体积直方图(DVH)流的开放知识规划(OpenKBP)挑战中获得亚军的模型的技术细节。该模型旨在确保训练简单且可重复,无需使用成本高昂的先进生成对抗网络(GAN)技术。

方法

该模型基于OpenKBP挑战数据集开发,分别包含200例和40例头颈部患者用于训练和验证。最终模型是一个U-Net,在上下卷积之间添加了ResNet块。通过使用带有单周期调度器的AdamW训练模型来获得结果。损失函数是L1损失与特征损失的组合,其中使用预训练的视频分类器作为特征提取器。在OpenKBP测试数据集中的另外100例患者上评估性能。评估测试数据的DVH指标,其中针对危及器官(OARs)计算 、 和 ,针对靶结构计算 、 和 。报告预测剂量与真实剂量之间的DVH指标差异百分比。

结果

该模型在OpenKBP挑战的DVH和剂量流中分别获得第二名和第四名。剂量和DVH分数分别为2.62±1.10和1.52±1.06。不同结构和DVH参数的平均剂量差异在±1%以内。

结论

这种直接的方法产生了优异的结果。它结合了单周期学习、ResNet和基于特征的损失,这些都是常见的计算机视觉技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0de/8518421/8fcf7a4d1a80/MP-48-5562-g002.jpg

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