Unit of Research 'Neurobehavioural mechanisms and endophenotypes of addictive behaviour', Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia, Spain.
Red Temática de Investigación Cooperativa en Salud (RETICS), Red de Trastornos Adictivos, Instituto de Salud Carlos III, MICINN and FEDER, Madrid, Spain; Unidad de Investigación Psicobiología de las Drogodependencias, Departamento de Psicobiología, Facultad de Psicología, Universitat de València, Valencia, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2021 Dec 20;111:110390. doi: 10.1016/j.pnpbp.2021.110390. Epub 2021 Jun 19.
Cocaine dependence is a highly prevalent disease in modern society and lacks an effective treatment. Cannabidiol (CBD), a major non-psychoactive constituent of Cannabis sativa, has been shown to be a promising tool in the management of some neuropsychiatric disorders, including cocaine abuse. However, its therapeutic effects on the behavioral outcomes related to cocaine addiction remain unclear. The present research evaluates the effects of CBD (30, 60 and 120 mg/kg; injected intraperitoneally) on the acquisition, expression, extinction and reinstatement of cocaine (10 mg/kg)-induced conditioned place preference (CPP; Study 1); cocaine (25 mg/kg)-induced locomotor stimulation (Study 2); and cocaine withdrawal symptoms (Study 3) in male C57BL/6 J mice. The results show that CBD does not possess motivational properties in itself and does not modify the acquisition, expression or extinction of cocaine-induced CPP. Interestingly, when administered during the extinction phase of the cocaine-induced CPP, CBD (30 and 60 mg/kg) prevented priming-induced reinstatement of CPP. Moreover, CBD abolished cocaine-induced hyperactivity without altering the spontaneous locomotion of the animals. Furthermore, CBD (120 mg/kg) reduced the memory deficits induced by cocaine withdrawal in the object recognition test, though it did not reverse depressive-like symptoms measured in the tail suspension test. Overall, our data suggest that CBD can prevent the development of cocaine addiction, and, when administered during cocaine abstinence, may be of help in avoiding relapse to drug-seeking and in ameliorating the memory disturbances provoked by chronic consumption of cocaine.
可卡因依赖是现代社会中一种高发疾病，目前缺乏有效的治疗方法。大麻中的主要非精神活性成分大麻二酚（CBD）已被证明是治疗某些神经精神疾病的有前途的工具，包括可卡因滥用。然而，其对与可卡因成瘾相关的行为结果的治疗效果尚不清楚。本研究评估了 CBD（30、60 和 120mg/kg；腹腔内注射）对可卡因（10mg/kg）诱导的条件性位置偏爱（CPP；研究 1）、可卡因（25mg/kg）诱导的运动刺激（研究 2）和可卡因戒断症状（研究 3）的影响在雄性 C57BL/6J 小鼠中。结果表明，CBD 本身没有动机特性，也不会改变可卡因诱导的 CPP 的获得、表达或消退。有趣的是，当在可卡因诱导的 CPP 的消退阶段给予 CBD（30 和 60mg/kg）时，它可以预防引发的 CPP 复燃。此外，CBD 消除了可卡因引起的过度活动，而不改变动物的自发运动。此外，CBD（120mg/kg）减少了可卡因戒断引起的物体识别测试中的记忆缺陷，尽管它没有逆转尾巴悬挂测试中测量的抑郁样症状。总的来说，我们的数据表明 CBD 可以预防可卡因成瘾的发展，并且在可卡因戒断期间给予 CBD 可能有助于避免复发和改善慢性可卡因消耗引起的记忆障碍。
