Neurobiology of Behaviour Research Group (GReNeC-NeuroBio), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain.
Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Sciences, Pharmacology Section and Institute of Biomedicine (IBUB), Universitat de Barcelona, 08028 Barcelona, Spain.
Int J Mol Sci. 2021 Aug 2;22(15):8304. doi: 10.3390/ijms22158304.
3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) and the most widespread and life-threatening synthetic cathinone of the "bath salts". Preclinical research has proven the cocaine-like psychostimulant effects of MDPV and its potential for abuse. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid that has emerged as a new potential treatment for drug addiction. Here, we tested the effects of CBD (20 mg/kg) on MDPV (2 mg/kg)-induced conditioned place preference and MDPV (0.05 and 0.075 mg/kg/infusion) self-administration paradigms. In addition, we assessed the effects of the co-administration of CBD and MDPV (3 and 4 mg/kg) on anxiety-like behaviour using the elevated plus maze (EPM). CBD mitigated the MDPV-induced conditioned place preference. On the contrary, CBD administration throughout the MDPV (0.075 mg/kg/infusion) self-administration increased drug-seeking and taking behaviours, but only in the high-responders group of mice. Furthermore, CBD exerted anxiolytic-like effects, exclusively in MDPV-treated mice. Taken together, our results indicate that CBD modulation of MDPV-induced motivational responses in mice varies depending on the requirements of the learning task, resulting in a complex response. Therefore, further research attempting to decipher the behavioural and molecular interactions between CBD and MDPV is needed.
3,4-亚甲二氧基吡咯戊酮（MDPV）是一种新的精神活性物质（NPS），也是“浴盐”中最广泛和最具生命威胁的合成卡西酮。临床前研究已经证明了 MDPV 类似可卡因的精神刺激作用及其滥用的潜力。大麻二酚（CBD）是一种非精神活性植物大麻素，已成为治疗药物成瘾的新潜在方法。在这里，我们测试了 CBD（20 mg/kg）对 MDPV（2 mg/kg）诱导的条件性位置偏好和 MDPV（0.05 和 0.075 mg/kg/输注）自我给药范式的影响。此外，我们评估了 CBD 和 MDPV（3 和 4 mg/kg）联合给药对高架十字迷宫（EPM）中焦虑样行为的影响。CBD 减轻了 MDPV 诱导的条件性位置偏好。相反，在 MDPV（0.075 mg/kg/输注）自我给药期间给予 CBD 会增加觅药和摄取行为，但仅在小鼠的高反应者组中。此外，CBD 表现出抗焦虑样作用，仅在 MDPV 处理的小鼠中。总之，我们的结果表明，CBD 对 MDPV 诱导的小鼠动机反应的调节因学习任务的要求而异，从而导致复杂的反应。因此，需要进一步研究试图阐明 CBD 和 MDPV 之间的行为和分子相互作用。
