Liu Liu, Liu Jianxing, Zhao Ming, Cai Meiming, Lei Fanzhang, Zeng Xiaofeng, Zhu Bofeng
Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.
School of Forensic Medicine, Kunming Medical University, Kunming, China.
Front Pharmacol. 2022 Nov 4;13:969883. doi: 10.3389/fphar.2022.969883. eCollection 2022.
Cannabidiol, a non-psychoactive component extracted from the plant cannabis sativa, has gained growing focus in recent years since its extensive pharmacology effects have been founded. The purpose of this study intends to reveal the hot spots and frontiers of cannabidiol research using bibliometrics and data visualization methods. A total of 3,555 publications with 106,793 citations from 2004 to 2021 related to cannabidiol were retrieved in the Web of Science database, and the co-authorships, research categories, keyword burst, and reference citations in the cannabidiol field were analyzed and visualized by VOSviewer and Citespace software. Great importance has been attached to the pharmacology or pharmacy values of cannabidiol, especially in the treatment of neuropsychiatric disorders, such as epilepsy, anxiety, and schizophrenia. The mechanisms or targets of the cannabidiol have attracted the extreme interest of the researchers, a variety of receptors including cannabinoids type 1, cannabinoids type 2, 5-hydroxytriptamine1A, and G protein-coupled receptor 55 were involved in the pharmacology effects of cannabidiol. Moreover, the latest developed topic has focused on the positive effects of cannabidiol on substance use disorders. In conclusion, this study reveals the development and transformation of knowledge structures and research hotspots in the cannabidiol field from a bibliometrics perspective, exploring the possible directions of future research.
大麻二酚是从植物大麻中提取的一种无精神活性成分，自其广泛的药理作用被发现以来，近年来受到了越来越多的关注。本研究旨在运用文献计量学和数据可视化方法揭示大麻二酚研究的热点和前沿。在科学网数据库中检索了2004年至2021年与大麻二酚相关的3555篇出版物，共106793次引用，并通过VOSviewer和Citespace软件对大麻二酚领域的合著情况、研究类别、关键词爆发和参考文献引用进行了分析和可视化。大麻二酚的药理或药学价值受到了高度重视，尤其是在治疗神经精神疾病方面，如癫痫、焦虑和精神分裂症。大麻二酚的作用机制或靶点引起了研究人员的极大兴趣，包括大麻素1型、大麻素2型、5-羟色胺1A和G蛋白偶联受体55在内的多种受体参与了大麻二酚的药理作用。此外，最新的研究热点集中在大麻二酚对物质使用障碍的积极作用上。总之，本研究从文献计量学角度揭示了大麻二酚领域知识结构的发展和转变以及研究热点，探索了未来研究的可能方向。
