Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, PR China; State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan Province 610041, PR China.
Department of Neurology, Air Force Hospital of Western Theater Command, Chengdu, Sichuan Province 610041, PR China.
Oral Oncol. 2021 Aug;119:105370. doi: 10.1016/j.oraloncology.2021.105370. Epub 2021 Jun 19.
Secretory carcinoma (SC) and acinic cell carcinoma (AciCC) are two rare tumors originating in the salivary gland of the head and neck. Before the World Health Organization (WHO) classified SC as a new entity in 2017, the majority of SC cases were incorrectly diagnosed as AciCC. Indeed, they are similar in biological behaviors, clinical manifestations and histomorphological features. Especially, SC and zymogen granule-poor AciCC are difficult to differentiate, which brings a tough challenge in clinical diagnosis. This article provides an updated understanding of the differential diagnosis in SC and AciCC from two main perspectives: histopathology and molecular genetics. The targeted therapies for both tumors are also mentioned. It aims to give some hints in clinical diagnosis and treatment, in hopes that patients with adequate diagnosis could obtain the opportunityformore effective treatment.
分泌性癌（SC）和涎腺闰管细胞癌（AciCC）是两种起源于头颈部唾液腺的罕见肿瘤。在世界卫生组织（WHO）于 2017 年将 SC 归类为一种新实体之前，大多数 SC 病例被错误地诊断为 AciCC。事实上，它们在生物学行为、临床表现和组织形态学特征上具有相似性。特别是，SC 和缺乏酶原颗粒的 AciCC 很难区分，这给临床诊断带来了很大的挑战。本文从组织病理学和分子遗传学两个主要方面对 SC 和 AciCC 的鉴别诊断进行了综述。同时也提到了两种肿瘤的靶向治疗。旨在为临床诊断和治疗提供一些提示，希望通过充分诊断，患者能有机会获得更有效的治疗。
