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上唇人中部位的分泌性癌:病例研究

Secretory Carcinoma of the Philtrum of the Upper Lip: A Case Study.

作者信息

Asuquo Jessica, Blavo Cyril, Bhatta Rabi

机构信息

Department of Clinical Education, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.

Department of Preclinical Education, Nova Southeastern University Dr. Kiran C. Patel College of Osteopathic Medicine, Davie, USA.

出版信息

Cureus. 2024 Sep 6;16(9):e68823. doi: 10.7759/cureus.68823. eCollection 2024 Sep.

DOI:10.7759/cureus.68823
PMID:39371716
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11456339/
Abstract

The parotid, submandibular, and sublingual salivary glands are the major salivary glands in the mouth. Cancers that arise in these glands are relatively uncommon, usually benign, and rarely metastasize. We present a unique case of a 17-year-old male diagnosed with high-grade secretory carcinoma of the salivary gland that was generally asymptomatic except for a persistent rash. The patient reported no significant past medical, family, or social history. A multidisciplinary team efficiently diagnosed and treated the cancer with histopathology, MRI, tumor excision, lymphadenectomy, and adjuvant treatment. Despite the rarity of the cancer, which was found in a high-grade regionally advanced disease, in an uncharacteristically young patient, the patient was effectively treated with adjuvant chemoradiotherapy without treatment-related complications.

摘要

腮腺、颌下腺和舌下腺是口腔中的主要唾液腺。这些腺体发生的癌症相对不常见,通常为良性,很少发生转移。我们报告了一例独特的病例,一名17岁男性被诊断为唾液腺高级别分泌性癌,除了持续出现皮疹外,一般没有症状。患者既往无重大病史、家族史或社会史。一个多学科团队通过组织病理学、MRI、肿瘤切除、淋巴结清扫和辅助治疗有效地诊断并治疗了该癌症。尽管这种癌症罕见,且发现时处于高级别局部晚期,患者年龄也非比寻常地小,但患者接受辅助放化疗后得到了有效治疗,且未出现与治疗相关的并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/11456339/e7a9a40895a3/cureus-0016-00000068823-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/11456339/982cc403ce56/cureus-0016-00000068823-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/11456339/e7a9a40895a3/cureus-0016-00000068823-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/11456339/982cc403ce56/cureus-0016-00000068823-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf0b/11456339/e7a9a40895a3/cureus-0016-00000068823-i02.jpg

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本文引用的文献

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Cancers (Basel). 2023 Aug 24;15(17):4246. doi: 10.3390/cancers15174246.
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Secretory carcinoma of the salivary gland, a rare entity: An international multi-institutional study.唾液腺癌,一种罕见的实体瘤:一项国际多机构研究。
Cancer Cytopathol. 2022 Sep;130(9):684-694. doi: 10.1002/cncy.22574. Epub 2022 Apr 6.
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Mammary analogue secretory carcinoma in minor salivary gland.小唾液腺中的乳腺样分泌性癌。
Einstein (Sao Paulo). 2022 Feb 14;20:eRC5724. doi: 10.31744/einstein_journal/2022RC5724. eCollection 2022.
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Diagnosis and treatment of secretory carcinoma arising from the oral minor salivary gland: Two case reports.来源于口腔小唾液腺的分泌性癌的诊断和治疗:两例报告。
Medicine (Baltimore). 2021 Dec 23;100(51):e28390. doi: 10.1097/MD.0000000000028390.
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Clinicopathological characteristics and outcomes of 23 patients with secretory carcinoma of major salivary glands.23 例涎腺大唾液腺癌的临床病理特征和转归。
Sci Rep. 2021 Nov 22;11(1):22639. doi: 10.1038/s41598-021-01970-4.
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Differential diagnosis and treatment of salivary secretory carcinoma and acinic cell carcinoma.涎腺分泌性癌与涎腺腺泡细胞癌的鉴别诊断与治疗。
Oral Oncol. 2021 Aug;119:105370. doi: 10.1016/j.oraloncology.2021.105370. Epub 2021 Jun 19.
7
A systematic review of secretory carcinoma of the salivary gland: where are we?唾液腺癌分泌型的系统回顾:我们现在处于什么位置?
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Oct;132(4):e143-e152. doi: 10.1016/j.oooo.2020.04.007. Epub 2020 May 31.
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Secretory carcinoma of the major salivary gland: Provincial population-based analysis of clinical behavior and outcomes.大唾液腺癌的分泌性癌:基于省级人群的临床行为和结局的分析。
Head Neck. 2019 May;41(5):1227-1236. doi: 10.1002/hed.25536. Epub 2018 Dec 28.
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Clinicopathologic and molecular characterization of mammary analogue secretory carcinoma of salivary gland origin.涎腺来源乳腺样分泌癌的临床病理及分子特征
Pathol Res Pract. 2017 Sep;213(9):1112-1118. doi: 10.1016/j.prp.2017.07.017. Epub 2017 Jul 23.
10
Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity.涎腺来源的乳腺样分泌性癌:近期描述实体的更新及扩展的形态学和免疫组化谱
Head Neck Pathol. 2013 Jul;7 Suppl 1(Suppl 1):S30-6. doi: 10.1007/s12105-013-0455-y. Epub 2013 Jul 3.