Department of Pathology, ESIC Medical College, Faridabad, India.
Department of ENT, ESIC Medical College, Faridabad, India.
Diagn Cytopathol. 2024 Jan;52(1):E19-E22. doi: 10.1002/dc.25232. Epub 2023 Oct 3.
Secretory carcinoma (SC) was originally described as mammary analogue secretory carcinoma (MASC). We present here a case of 33 years old male who came to ENT outpatient department with a complaint of swelling over the left side of his neck for 8 months. On Fine-needle aspiration cytology, an impression of cytomorphological features suggestive of acinic cell carcinoma (Milan category V) was given. Left functional endoscopic sinus surgery was done. On histopathology, a final impression of Secretory carcinoma, the left submandibular gland was given with pathological stage classification as pT2N0Mx. SC of the salivary gland is a rare entity that may pose diagnostic challenges. Awareness of its cytologic features is paramount to achieve an accurate diagnosis. Morphologic interpretation must be supported by an immunohistochemical profile and molecular studies to confirm a diagnosis of SC.
分泌性癌（SC）最初被描述为乳腺类似物分泌性癌（MASC）。我们在此报告 1 例 33 岁男性患者，因左侧颈部肿胀 8 个月就诊于耳鼻喉科门诊。细针穿刺细胞学检查提示腺样囊性癌（米兰分类 V）的细胞学特征。行左侧功能性内镜鼻窦手术。组织病理学检查，左颌下腺最终诊断为分泌性癌，病理分期为 pT2N0Mx。唾液腺的 SC 是一种罕见的实体瘤，可能会带来诊断上的挑战。对其细胞学特征的认识对于获得准确的诊断至关重要。形态学解释必须通过免疫组织化学特征和分子研究来支持，以确认 SC 的诊断。
