局部晚期乳腺癌（T3、T4）的预后因素，特别涉及肿瘤细胞DNA含量
Prognostic factors in locally advanced breast cancer (T3, T4) with special reference to tumor cell DNA content.
作者信息
Arnerlöv C, Emdin S O, Roos G, Angström T, Bjersing L, Angquist K A, Larsson L G, Jonsson H
机构信息
Department of Surgery, University Hospital, University of Umeå, Sweden.
出版信息
Acta Oncol. 1988;27(3):221-6. doi: 10.3109/02841868809093529.
The prognostic value of DNA analysis was studied retrospectively in 91 patients with locally advanced breast cancer (T3, T4) and a follow-up time of 3-7 years. Tumor cell DNA analysis was performed by static cytometry on aspiration biopsy specimens in 42 cases and on tissue sections in 49 cases. The tumors were classified as euploid or aneuploid. Sixty-four percent of the tumors were aneuploid. DNA pattern correlated significantly to histologic grade and axillary perinodal growth and also to survival. DNA pattern, histologic grade and axillary node metastases correlated significantly to disease-free survival (DFS). In this series of patients with locally advanced breast cancer DNA determinations gave important prognostic information.
对91例局部晚期乳腺癌（T3、T4）患者进行了回顾性研究，随访时间为3至7年，以评估DNA分析的预后价值。42例患者通过静态细胞计数法对针吸活检标本进行肿瘤细胞DNA分析，49例患者对组织切片进行分析。肿瘤被分类为整倍体或非整倍体。64%的肿瘤为非整倍体。DNA模式与组织学分级、腋窝淋巴结周围生长以及生存率显著相关。DNA模式、组织学分级和腋窝淋巴结转移与无病生存期（DFS）显著相关。在这组局部晚期乳腺癌患者中，DNA检测提供了重要的预后信息。
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