von Rosen A, Rutqvist L E, Carstensen J, Fallenius A, Skoog L, Auer G
Department of Surgery, Södersjukhuset, Stockholm, Sweden.
Breast Cancer Res Treat. 1989 Jan;13(1):23-32. doi: 10.1007/BF01806547.
The prognostic value of nuclear DNA distribution pattern in relation to tumor size, axillary lymph node status, and estrogen receptor (ER) content was studied in 464 patients with primary, operable mammary adenocarcinoma. The median follow-up time was 3 1/2 years. Slide cytophotometric DNA analysis was performed on morphologically identified Feulgen-stained tumor cells. The tumors were classified into four subgroups according to their DNA histogram type. DNA content was significantly related to tumor size and ER level but not to nodal status. When all variables were stimultaneously introduced into Cox's proportional hazards model, tumor size, nodal status, and DNA profile remained as significant predictors of recurrence. Restricting the analysis to node-negative patients, both DNA profile and tumor size showed a significant prognostic value. DNA did not contribute significant prognostic information in node-positive patients. However, the trends in recurrence-free survival were similar to those in the node-negative subgroup: patients with aneuploid tumors tended to fare worse than those with euploid carcinomas.
在464例原发性可手术乳腺腺癌患者中，研究了核DNA分布模式与肿瘤大小、腋窝淋巴结状态及雌激素受体（ER）含量的预后价值。中位随访时间为3.5年。对形态学鉴定的福尔根染色肿瘤细胞进行玻片细胞光度法DNA分析。根据DNA直方图类型将肿瘤分为四个亚组。DNA含量与肿瘤大小和ER水平显著相关，但与淋巴结状态无关。当将所有变量同时纳入Cox比例风险模型时，肿瘤大小、淋巴结状态和DNA谱仍然是复发的重要预测因素。将分析局限于淋巴结阴性患者，DNA谱和肿瘤大小均显示出显著的预后价值。DNA在淋巴结阳性患者中未提供显著的预后信息。然而，无复发生存趋势与淋巴结阴性亚组相似：非整倍体肿瘤患者的预后往往比整倍体癌患者差。
