Jasumback C L, Dlamini Q, Kahari J, Maphalala G, Dlamini M G, Dube G S, DiNardo A, Kirchner H L, Mandalakas A, Kay A W
United States Peace Corps, Mbabane, Eswatini.
Baylor College of Medicine Children's Foundation-Eswatini, Mbabane, Eswatini.
Public Health Action. 2021 Jun 21;11(2):55-57. doi: 10.5588/pha.20.0079.
TB disease diagnosis in children is difficult due to non-specific symptoms, paucibacillary disease and the need for invasive procedures to obtain diagnostic specimens. In many settings, these specimens are simply not collected and therefore stool, easily obtained, has emerged as a promising specimen for the diagnosis of child TB. In this study, stool from a healthy adult was spiked with known concentrations of bacille Calmette-Guérin vaccine and tested using the Xpert Ultra assay to determine the relative detection and error rate associated with four different published stool processing methods.
由于儿童结核病的症状不具特异性、菌量少以及需要通过侵入性操作获取诊断标本，因此儿童结核病的诊断较为困难。在许多情况下，根本无法采集到这些标本，所以易于获取的粪便已成为诊断儿童结核病的一种很有前景的标本。在本研究中，将已知浓度的卡介苗接种到健康成年人的粪便中，并使用Xpert Ultra检测法进行检测，以确定与四种不同的已发表粪便处理方法相关的相对检测率和错误率。
