Ndifor Ache Roland, Stanislaus Njinga Ngaitad, Fru Chi Godloves, Talontsi Ferdinand, Tabopda Turibio Kuiate, Menkem Elisabeth Zeuko'o, Tchaleu Ngadjui Bonaventure, Owusu Yeboah Samuel
Higher Technical Teacher Training College, University of Bamenda, Cameroon.
Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Ilorin, Nigeria.
Biochem Biophys Rep. 2021 Jun 11;27:101014. doi: 10.1016/j.bbrep.2021.101014. eCollection 2021 Sep.
commonly known as Bang Bali in Bali-Nguemba, Cameroon is used in traditional medicine against various diseases. The leaves and stem bark extracts were subjected to silica gel and Sephadex LH column chromatography to yield pure compounds. The structures of the compounds were determined by detail analysis of NMR and Mass spectroscopic data and by comparison with data reported in the literature. Amongst the isolates, were two new sphingolipids: synsepaloside B (), synsepaloside C (), and five known compounds: (+)-catechin (), (-)-epicatechin (), myricitrin (), triacontanol (), and aurantiamide acetate (). Compounds - were screened for their antibacterial and anti-yeast activities on several microorganisms. All the tested compounds exhibited weak antibacterial (MIC 200 μg/mL) and anti-yeast (MIC > 200 μg/mL) activities as compared to standard: ciprofloxacin 0.468 < MIC >0.234 μg/mL and fluconazole MIC = 0.05 μg/mL, respectively.
在喀麦隆的巴厘-恩圭姆巴通常被称为邦巴利,它被用于传统医学治疗各种疾病。对其叶和茎皮提取物进行硅胶和葡聚糖凝胶LH柱色谱分离以得到纯化合物。通过对核磁共振(NMR)和质谱数据的详细分析并与文献报道的数据进行比较来确定化合物的结构。在分离出的化合物中,有两种新的鞘脂类化合物:合萼木苷B()、合萼木苷C(),以及五种已知化合物:(+)-儿茶素()、(-)-表儿茶素()、杨梅苷()、三十烷醇()和乙酸橙酰胺()。对化合物-在几种微生物上进行了抗菌和抗酵母活性筛选。与标准品相比,所有测试化合物均表现出较弱的抗菌活性(最低抑菌浓度(MIC)>200μg/mL)和抗酵母活性(MIC>200μg/mL),标准品环丙沙星的MIC为0.468