Yang Guohua, Sandjo Louis, Yun Keumja, Leutou Alain Simplice, Kim Gun-Do, Choi Hong Dae, Kang Jung Sook, Hong Jongki, Son Byeng Wha
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Chem Pharm Bull (Tokyo). 2011;59(9):1174-7. doi: 10.1248/cpb.59.1174.
Flavusides A (1) and B (2), two new antibacterial cerebroside derivatives, and the previously described phomaligol A (3), kojic acid (4), methyl kojic acid (5), and dimethyl kojic acid (6) have been isolated from the extract of a marine isolate of the fungus Aspergillus flavus. The structure and absolute stereochemistry of two cerebrosides were assigned on the basis of NMR and Tandem FAB-MS/MS experiments. Compounds 1, 2, and 3 exhibited a mild antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus, and multidrug-resistant S. aureus. The minimum inhibitory concentration (MIC) values for each strain are as follows: compounds 1 and 2 showed 15.6 μg/ml for S. aureus and 31.2 μg/ml for methicillin-resistant S. aureus and multidrug-resistant S. aureus, and compound 3 exhibited 31.2 μg/ml for S. aureus and methicillin-resistant S. aureus and 62.5 μg/ml for multidrug-resistant S. aureus.
从黄曲霉海洋分离株的提取物中分离出了两种新的具有抗菌活性的脑苷脂衍生物——黄曲苷A（1）和黄曲苷B（2），以及之前报道过的腐皮镰刀菌醇A（3）、曲酸（4）、甲基曲酸（5）和二甲基曲酸（6）。基于核磁共振（NMR）和串联快原子轰击质谱/质谱（Tandem FAB-MS/MS）实验确定了两种脑苷脂的结构和绝对立体化学。化合物1、2和3对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌和多重耐药金黄色葡萄球菌表现出轻度抗菌活性。每种菌株的最低抑菌浓度（MIC）值如下：化合物1和2对金黄色葡萄球菌的MIC值为15.6μg/ml，对耐甲氧西林金黄色葡萄球菌和多重耐药金黄色葡萄球菌的MIC值为31.2μg/ml；化合物3对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌的MIC值为31.2μg/ml，对多重耐药金黄色葡萄球菌的MIC值为62.5μg/ml。
