Department of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Rome; Unit of Psychiatry, 'Sant'Andrea' University Hospital, Via di Grottarossa 1035-1039, 00189 Rome, Italy - Email:
Arch Ital Biol. 2021 Mar 31;159(1):3-20. doi: 10.12871/00039829202111.
Cortical thickness (CT) and local gyrification index (LGI) in psychotic disorders may show modifications that relate to clinical course. This observational study aimed to analyse such variables in patients with schizophrenia, compared to healthy controls (HCs). We compared CT and LGI of 18 patients with first-episode psychosis with that of 21 with multi-episode schizophrenia and 16 HCs. CT corrected for false-positive cases (Family-Wise Error Rate) showed a reduction in the multi-episode group compared to HCs in left temporal and parietal, and right temporal, parietal, occipital, and hippocampal cortices. Family-wise corrected LGI was increased in the left inferior and middle frontal cortices, and in the right fusiform gyrus, cingulate, lingual, and parahippocampal gyri in first onset patients compared to HCs. Increased LGI was absent from later stages of psychosis, suggesting that specific CT and LGI alterations may underlie different stages of illness.
皮质厚度 (CT) 和局部脑回指数 (LGI) 在精神障碍中可能存在与临床病程相关的改变。本观察性研究旨在分析首发精神病患者与健康对照组 (HC) 之间的这些变量。我们比较了 18 例首发精神病患者、21 例反复发作精神分裂症患者和 16 例 HCs 的 CT 和 LGI。经假阳性病例校正 (Family-Wise Error Rate) 的 CT 显示，多发作组与 HCs 相比，左侧颞叶和顶叶以及右侧颞叶、顶叶、枕叶和海马皮质的 CT 值降低。与 HCs 相比，首发患者左侧额下回和中回以及右侧梭状回、扣带回、舌回和海马旁回的校正后的 LGI 增加。精神分裂症后期阶段不存在增加的 LGI，这表明特定的 CT 和 LGI 改变可能是疾病不同阶段的基础。
