Harvard University, United States of America; Beth Israel Deaconess Medical Center, United States of America.
Harvard University, United States of America; Beth Israel Deaconess Medical Center, United States of America; Harvard Medical School, United States of America; VA Boston HealthCare System, United States of America.
Schizophr Res. 2024 Sep;271:169-178. doi: 10.1016/j.schres.2024.07.009. Epub 2024 Jul 19.
The profiles of cortical gyrification across schizophrenia, bipolar I disorder, and schizoaffective disorder have been studied to a limited extent, report discordant findings, and are rarely compared in the same study. Here we assess gyrification in a large dataset of psychotic disorder probands, categorized according to the DSM-IV. Furthermore, we explore gyrification changes with age across healthy controls and probands.
Participants were recruited within the Bipolar-Schizophrenia Network of Intermediate Phenotypes study and received T1-MPRAGE and clinical assessment. Gyrification was measured using FreeSurfer 7.1.0. Pairwise t-tests were conducted in R, and age-related gyrification changes were analyzed in MATLAB. P values <0.05 after false discovery rate correction were considered significant.
Significant hypogyria in schizophrenia, bipolar disorder, and schizoaffective disorder probands compared to controls was found, with a significant difference bilaterally in the frontal lobe between schizophrenia and bipolar disorder probands. Verbal memory was associated with gyrification in the right frontal and right cingulate cortex in schizophrenia. Age-fitted gyrification curves differed significantly among psychotic disorders and controls.
Findings indicate hypogyria in DSM-IV psychotic disorders compared to controls and suggest differential patterns of gyrification across the different diagnoses. The study extends age related models of gyrification to psychotic disorder probands and supports that age-related differences in gyrification may differ across diagnoses. Fitted gyrification curves among probands categorized by DSM-IV significantly deviate from controls, with the model capturing early hypergyria and later hypogyria in schizophrenia compared to controls; this suggests unique disease and age-related changes in gyrification across psychotic disorders.
精神分裂症、双相情感障碍 I 型和分裂情感障碍的皮质脑回形态学特征已在一定程度上进行了研究，但研究结果存在差异，且很少在同一研究中进行比较。在这里，我们根据 DSM-IV 对大量精神病患者样本进行了脑回形态学评估。此外，我们还探索了健康对照组和患者组中脑回形态随年龄的变化。
参与者是在双相情感障碍-精神分裂症网络中间表型研究中招募的，并接受了 T1-MPRAGE 和临床评估。使用 FreeSurfer 7.1.0 测量脑回形态。在 R 中进行了配对 t 检验，在 MATLAB 中分析了与年龄相关的脑回形态变化。校正假发现率后 P 值<0.05 被认为具有统计学意义。
与对照组相比，精神分裂症、双相情感障碍和分裂情感障碍患者的脑回明显减少，精神分裂症和双相情感障碍患者的额叶双侧存在显著差异。精神分裂症患者的言语记忆与右侧额叶和右侧扣带回皮质的脑回形态有关。不同精神障碍患者和对照组的年龄拟合脑回形态曲线存在显著差异。
研究结果表明，与对照组相比，DSM-IV 精神障碍患者存在脑回减少，并提示不同诊断之间存在不同的脑回形态模式。该研究将脑回形态的年龄相关模型扩展到了精神病患者，并支持脑回形态的年龄相关差异可能因诊断而异。根据 DSM-IV 分类的患者拟合脑回形态曲线与对照组显著不同，与对照组相比，该模型捕捉到了精神分裂症患者早期的过度脑回和后期的减少，这表明不同的精神障碍患者在脑回形态上存在独特的疾病和年龄相关变化。
