School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan, Road, Shanghai, 200240, China.
Biomater Sci. 2021 Aug 7;9(15):5092-5115. doi: 10.1039/d1bm00721a. Epub 2021 Jun 23.
The current treatment strategies for cancer therapy have posed many problems in achieving high efficacy. Therefore, an urgent step is needed to develop innovative therapies that can win beyond satisfactory results against tumor. Ferroptosis that is a kind of non-apoptotic based programmed cell death has played a crucial role in eradicating tumors by reactive oxygen species and iron-dependent pathways. Research shows a remarkable potential of ferroptosis in eliminating aggressive malignancies resistant to traditional therapies. The combination of nanomedicine and ferroptosis has revealed a close relationship for the treatment of various cancer types with high efficacy. This review introduces the basics of nanomedicine-based ferroptosis first to emphasize the feasibility and properties of ferroptosis in cancer therapy. Then, the current research on the applications of nanomedicine for the ferroptosis-based anticancer therapy is highlighted. Finally, conclusions and future research directions in perspective of various challenges in developing nanomedicine-based ferroptosis into clinical therapeutics are discussed.
目前癌症治疗的策略在实现高效方面存在诸多问题。因此，迫切需要开发创新疗法，通过活性氧和铁依赖性途径获得超越肿瘤治疗满意效果的治疗方法。铁死亡是一种非凋亡性的程序性细胞死亡，通过活性氧和铁依赖性途径在消除肿瘤方面发挥着关键作用。研究表明，铁死亡在消除对传统疗法具有耐药性的侵袭性恶性肿瘤方面具有显著的潜力。纳米医学和铁死亡的结合为高效治疗各种癌症类型提供了密切的关系。本综述首先介绍了基于纳米医学的铁死亡基础，以强调铁死亡在癌症治疗中的可行性和特性。然后，重点介绍了纳米医学在基于铁死亡的抗癌治疗中的应用的最新研究。最后，讨论了开发基于纳米医学的铁死亡向临床治疗转化所面临的各种挑战的结论和未来研究方向。
