Liu Yurong, Liu Yunheng, Li Xinting, Li Song, Zhang Xiaokang, Si Longqing, Jiang Shaojing, Hu Jinghui, Chen Jing
School of Pharmacy, The Key Laboratory of Prescription Effect and Clinical Evaluation of State Administration of Traditional Chinese Medicine of China, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Yantai Engineering Research Center for Digital Technology of Stomatology, Characteristic Laboratories of Colleges and Universities in Shandong Province for Digital Stomatology, Institute of Stomatology, Binzhou Medical University, Yantai, 264003, People's Republic of China.
Int J Nanomedicine. 2025 Feb 25;20:2461-2473. doi: 10.2147/IJN.S508767. eCollection 2025.
Ferroptosis is a type of iron-dependent programmed cell death characterized by a depletion of glutathione. Although generally less harmful to normal cells, in tumor cells, the high demand for iron ions provides conditions conducive to ferroptosis. In this review, we provide an overview of recent progress in research on the regulation of ferroptosis in tumor cells, summarizing and assessing the current state, trends, and applications of nanomaterials in the regulation of ferroptosis in tumor cells. Given the advantages of nanomaterials in terms of targeting, safety, improved drug efficacy, and reduced side effects, these materials are considered to have potential therapeutic value in modulating ferroptosis in tumor cells via different mechanisms. In this respect, we describe methods for modifying the regulation of iron ions and interfering with glutathione activity and lipid peroxidation. The development of nanomaterials that can be applied to induce or inhibit ferroptosis is anticipated to provide new therapeutic options for the treatment of a diverse range of diseases.
铁死亡是一种铁依赖性程序性细胞死亡，其特征是谷胱甘肽耗竭。虽然一般对正常细胞危害较小，但在肿瘤细胞中，对铁离子的高需求为铁死亡提供了有利条件。在这篇综述中，我们概述了肿瘤细胞中铁死亡调控研究的最新进展，总结并评估了纳米材料在肿瘤细胞铁死亡调控中的现状、趋势和应用。鉴于纳米材料在靶向性、安全性、提高药物疗效和减少副作用方面的优势，这些材料被认为通过不同机制调节肿瘤细胞铁死亡具有潜在的治疗价值。在这方面，我们描述了调节铁离子、干扰谷胱甘肽活性和脂质过氧化的方法。有望开发出可用于诱导或抑制铁死亡的纳米材料，为治疗多种疾病提供新的治疗选择。
