Department of Cardiology, Babol University of Medical Sciences, Babol, Iran.
Clinical Research Development unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
Int J Cardiovasc Imaging. 2021 Nov;37(11):3279-3283. doi: 10.1007/s10554-021-02317-w. Epub 2021 Jun 23.
Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinophilia and organ involvement. Here, we report a patient with COVID-19 who presented with clot formation and myocarditis. One month after discharge, regarding persistent peripheral/bone marrow hypereosinophilia and clot in echocardiography, fluorescent in situ hybridization (FISH) analysis was done that showed FIP1L1-CHIC2 fusion (PDGFRɑ rearrangement) in 18% of scored cells and PDGFRβ rearrangement in 12% of scored cells, which confirmed HES diagnosis. Clot formation may be a late manifestation of COVID-19 or myocarditis due to COVID-19, or the first manifestation of HES that COVID-19 might provoke in this rare syndrome.
患有 2019 年冠状病毒病（COVID-19）的患者常有频繁的临床表现。它可能与多器官和心血管受累有关，如心肌炎和血栓形成。嗜酸性粒细胞增多综合征（HES）是一种罕见疾病，其诊断标准为特发性嗜酸性粒细胞增多和器官受累。在这里，我们报告了一名 COVID-19 患者，该患者表现为血栓形成和心肌炎。出院后一个月，由于外周血/骨髓嗜酸性粒细胞持续增多和超声心动图中的血栓，进行了荧光原位杂交（FISH）分析，结果显示 18%评分细胞中存在 FIP1L1-CHIC2 融合（PDGFRɑ 重排），12%评分细胞中存在 PDGFRβ 重排，这证实了 HES 的诊断。血栓形成可能是 COVID-19 或 COVID-19 导致的心肌炎的晚期表现，也可能是 COVID-19 引发这种罕见综合征的 HES 的首发表现。
