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利用部分 N 基因序列作为监测埃塞俄比亚狂犬病控制和消除工作进展的工具。

Use of partial N-gene sequences as a tool to monitor progress on rabies control and elimination efforts in Ethiopia.

机构信息

Ohio State University Global One Health Initiative, Columbus, OH, USA.

Ethiopian Public Health Institute, Gulele Sub City, Addis Ababa, Ethiopia.

出版信息

Acta Trop. 2021 Sep;221:106022. doi: 10.1016/j.actatropica.2021.106022. Epub 2021 Jun 20.

Abstract

Ethiopia is one of the African countries most affected by rabies. A coarse catalog of rabies viruses (RABV) was created as a benchmark to assess the impact of control and elimination activities. We evaluated a 726 bp amplicon at the end of the N-gene to infer viral lineages in circulation using maximum likelihood and Bayesian methods for phylogenetic reconstruction. We sequenced 228 brain samples from wild and domestic animals collected in five Ethiopian regions during 2010-2017. Results identified co-circulating RABV lineages that are causing recurrent spillover infections into wildlife and domestic animals. We found no evidence of importation of RABVs from other African countries or vaccine-induced cases in the area studied. A divergent RABV lineage might be involved in an independent rabies cycle in jackals. This investigation provides a feasible approach to assess rabies control and elimination efforts in resource-limited countries.

摘要

埃塞俄比亚是受狂犬病影响最严重的非洲国家之一。创建了一个粗略的狂犬病病毒 (RABV) 目录作为基准,以评估控制和消除活动的影响。我们使用最大似然法和贝叶斯方法评估了 N 基因末端的 726bp 扩增子,以推断传播中的病毒谱系。我们对 2010-2017 年期间在埃塞俄比亚五个地区采集的野生动物和家养动物的 228 个脑组织样本进行了测序。结果确定了循环传播的 RABV 谱系,这些谱系导致野生动物和家养动物反复发生溢出感染。在研究区域内未发现从其他非洲国家输入 RABV 或疫苗诱导病例的证据。一种差异较大的 RABV 谱系可能与豺狼中独立的狂犬病周期有关。这项调查提供了一种可行的方法来评估资源有限国家的狂犬病控制和消除工作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fedb/8652542/210eaa980e35/nihms-1758598-f0001.jpg

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