Garcés-Ayala Fabiola, Aréchiga-Ceballos Nidia, Ortiz-Alcántara Joanna M, González-Durán Elizabeth, Pérez-Agüeros Sandra I, Méndez-Tenorio Alfonso, Torres-Longoria Belem, López-Martínez Irma, Hernández-Rivas Lucía, Díaz-Quiñonez José Alberto, Ramírez-González José Ernesto
Instituto de Diagnóstico y Referencia Epidemiológicos "Dr. Manuel Martínez Báez" (InDRE), Secretaría de Salud, Francisco de P. Miranda 177, Lomas de Plateros, Álvaro Obregón, 01480, Mexico City, Mexico.
Escuela Nacional de Ciencias Biológicas (ENCB), Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala S/N, Casco de Santo Tomás, Miguel Hidalgo, 11340, Mexico City, Mexico.
Arch Virol. 2017 Dec;162(12):3629-3637. doi: 10.1007/s00705-017-3529-4. Epub 2017 Aug 17.
Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed. Phylogenetic analyses on the RNA sequences unveiled that the three atypical strains from Yucatan are associated with skunks. Analysis using the virus entire genome showed that they belong to a different lineage distinct from the variants described for this animal species in Mexico. The Chiapas atypical strain was grouped in a lineage that was considered extinct, while the others are clustered within classic dog variants.
狂犬病是一种传染性病毒疾病，临床症状出现后几乎总是致命的。在墨西哥，2006年报告了最后一例由狗传播的人类狂犬病病例，由于该国开展的疫苗接种运动，犬类狂犬病已显著下降。在此，我们报告了在尤卡坦州和恰帕斯州发现的6株狂犬病病毒株的分子特征，值得注意的是，当用一组减少到8种单克隆抗体进行抗原特征分析时，其中4株表现出非典型反应模式。对RNA序列的系统发育分析表明，来自尤卡坦州的3株非典型毒株与臭鼬有关。使用病毒全基因组进行分析表明，它们属于一个不同于墨西哥描述的该动物物种变体的不同谱系。恰帕斯州的非典型毒株被归为一个被认为已灭绝的谱系，而其他毒株则聚集在经典的犬类变体中。
