Olsen J H, Winther J, Brown P N
Danish Cancer Registry, Institute of Cancer Epidemiology, Copenhagen.
Hum Genet. 1990 Aug;85(3):283-7. doi: 10.1007/BF00206747.
The increased risk of nonocular cancer seen consistently in studies of survivors of retinoblastoma may be caused in part by the presence of a retinoblastoma gene that also predisposes to other cancers. It has been claimed that this gene also increases the risk for cancer among unaffected relatives of genetic retinoblastoma probands. We report here a population-based study of the risk of nonocular cancer in parents and siblings of persons notified to the Danish Cancer Registry with retinoblastoma during 1943-84. No excess was observed among first degree relatives of 61 genetic retinoblastoma probands, whereas a slight (10%) excess was seen among the parents of 115 nongenetic probands. The latter was the result of significant excesses of malignant melanoma (4 observed, 0.4 expected), multiple myeloma (2 observed, 0.2 expected) and osteogenic sarcoma (1 observed, 0.03 expected). The observed risk pattern cannot be explained by the presence of the retinoblastoma gene.
在视网膜母细胞瘤幸存者的研究中一直观察到的非眼部癌症风险增加，可能部分是由一种视网膜母细胞瘤基因的存在所致，该基因也易引发其他癌症。据称，这种基因还会增加遗传性视网膜母细胞瘤先证者未患病亲属患癌的风险。我们在此报告一项基于人群的研究，该研究针对1943年至1984年间被通知至丹麦癌症登记处的视网膜母细胞瘤患者的父母和兄弟姐妹患非眼部癌症的风险。在61名遗传性视网膜母细胞瘤先证者的一级亲属中未观察到超额风险，而在115名非遗传性先证者的父母中观察到轻微（10%）超额风险。后者是恶性黑色素瘤（观察到4例，预期0.4例）、多发性骨髓瘤（观察到2例，预期0.2例）和成骨肉瘤（观察到1例，预期0.03例）显著超额的结果。观察到的风险模式无法用视网膜母细胞瘤基因的存在来解释。
