Abramson D H, Marks R F, Ellsworth R M, Tretter P, Kitchin F D
Arch Ophthalmol. 1982 Aug;100(8):1249-52. doi: 10.1001/archopht.1982.01030040227002.
Sixty-six patients were treated "conservatively" for unilateral retinoblastoma. Forty-eight of 57 (84%) were treated primarily with unilateral radiation, one patient was treated with a cobalt plaque, and eight patients were treated with either cryopexy or xenon arc photocoagulation. With a median follow-up of 73 months, there have been no deaths. Five of 39 eyes that were in groups I to III have been salvaged. Virtually all eyes in groups IV and V (12 of 14) came to enucleation. The age at diagnosis for patients with a positive family history was early (2.5 months), and the patients had a greater number of individual tumors in one eye (2.4), compared with those without a positive family history (27 months, 1.2 tumors per eye). When unilateral retinoblastoma is detected at an early age, the most common sign is strabismus, not leukokoria.
66例单侧视网膜母细胞瘤患者接受了“保守”治疗。57例中的48例（84%）主要接受单侧放疗，1例接受钴板敷贴治疗，8例接受冷冻疗法或氙弧光凝治疗。中位随访73个月，无死亡病例。I至III组的39只眼中有5只眼视力得以挽救。IV组和V组几乎所有的眼睛（14只中的12只）都接受了眼球摘除术。有家族史阳性的患者诊断时年龄较早（2.5个月），与无家族史阳性的患者相比（27个月，每只眼1.2个肿瘤），这些患者单眼的单个肿瘤数量更多。当单侧视网膜母细胞瘤在早期被检测到时，最常见的体征是斜视，而非白瞳症。
