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“长新冠”难题:一篇叙述性综述

The Conundrum of 'Long-COVID-19': A Narrative Review.

作者信息

Garg Mandeep, Maralakunte Muniraju, Garg Suruchi, Dhooria Sahajal, Sehgal Inderpaul, Bhalla Ashu Seith, Vijayvergiya Rajesh, Grover Sandeep, Bhatia Vikas, Jagia Priya, Bhalla Ashish, Suri Vikas, Goyal Manoj, Agarwal Ritesh, Puri Goverdhan Dutt, Sandhu Manavjit Singh

机构信息

Department of Radiodiagnosis & Imaging, PGIMER, Chandigarh, India.

Department of Dermatology, Aura Skin Institute, Chandigarh, India.

出版信息

Int J Gen Med. 2021 Jun 14;14:2491-2506. doi: 10.2147/IJGM.S316708. eCollection 2021.

Abstract

COVID-19 is an ongoing pandemic with many challenges that are now extending to its intriguing long-term sequel. 'Long-COVID-19' is a term given to the lingering or protracted illness that patients of COVID-19 continue to experience even in their post-recovery phase. It is also being called 'post-acute COVID-19', 'ongoing symptomatic COVID-19', 'chronic COVID-19', 'post COVID-19 syndrome', and 'long-haul COVID-19'. Fatigue, dyspnea, cough, headache, brain fog, anosmia, and dysgeusia are common symptoms seen in Long-COVID-19, but more varied and debilitating injuries involving pulmonary, cardiovascular, cutaneous, musculoskeletal and neuropsychiatric systems are also being reported. With the data on Long-COVID-19 still emerging, the present review aims to highlight its epidemiology, protean clinical manifestations, risk predictors, and management strategies. With the re-emergence of new waves of SARS-CoV-2 infection, Long-COVID-19 is expected to produce another public health crisis on the heels of current pandemic. Thus, it becomes imperative to emphasize this condition and disseminate its awareness to medical professionals, patients, the public, and policymakers alike to prepare and augment health care facilities for continued surveillance of these patients. Further research comprising cataloging of symptoms, longer-ranging observational studies, and clinical trials are necessary to evaluate long-term consequences of COVID-19, and it warrants setting-up of dedicated, post-COVID care, multi-disciplinary clinics, and rehabilitation centers.

摘要

新冠疫情仍在持续,面临诸多挑战,如今这些挑战已延伸至其引人关注的长期后遗症。“长新冠”指的是新冠患者即便在康复后阶段仍持续经历的迁延不愈或持续时间较长的病症。它也被称作“新冠后急性疾病”“持续性有症状新冠”“慢性新冠”“新冠后综合征”以及“长途新冠”。疲劳、呼吸困难、咳嗽、头痛、脑雾、嗅觉丧失和味觉障碍是长新冠常见的症状,但也有报告称出现了更多种类且使人衰弱的损伤,累及肺部、心血管、皮肤、肌肉骨骼和神经精神系统。鉴于长新冠的数据仍在不断涌现,本综述旨在突出其流行病学、多样的临床表现、风险预测因素及管理策略。随着新冠病毒新一波感染的再度出现,长新冠预计将在当前疫情之后引发另一场公共卫生危机。因此,必须强调这种情况,并向医疗专业人员、患者、公众和政策制定者普及相关知识,以便为持续监测这些患者做好准备并加强医疗设施建设。有必要开展进一步研究,包括对症状进行编目、进行更长期的观察性研究以及开展临床试验,以评估新冠的长期后果,同时还需要设立专门的新冠后护理多学科诊所和康复中心。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bb7/8214209/a769b4329a2f/IJGM-14-2491-g0001.jpg

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