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Chilblain-like acral lesions in long COVID-19: management and implications for understanding microangiopathy.长新冠中的冻疮样肢端病变：管理及对理解微血管病的意义
Lancet Infect Dis. 2021 Jul;21(7):912. doi: 10.1016/S1473-3099(21)00133-X. Epub 2021 Mar 8.
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Chilblain-like acral lesions during the COVID-19 pandemic ("COVID toes"): Histologic, immunofluorescence, and immunohistochemical study of 17 cases.COVID-19 大流行期间的冻疮样肢端皮损（“COVID 脚趾”）：17 例的组织学、免疫荧光和免疫组化研究。
J Am Acad Dermatol. 2020 Sep;83(3):870-875. doi: 10.1016/j.jaad.2020.05.145. Epub 2020 Jun 2.
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No SARS-CoV-2 antibody response in 25 patients with pseudo-chilblains.25 例假性冻疮患者均未出现 SARS-CoV-2 抗体应答。
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Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on polymerase chain reaction and serology testing.在 COVID-19 疫情期间观察到的大多数冻疮样疹发生在聚合酶链反应和血清学检测 COVID-19 为阴性的患者中。
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Major cluster of paediatric 'true' primary chilblains during the COVID-19 pandemic: a consequence of lifestyle changes due to lockdown.新冠大流行期间儿童“真性”冻疮的大量聚集：封锁导致生活方式改变的后果。
J Eur Acad Dermatol Venereol. 2020 Nov;34(11):2630-2635. doi: 10.1111/jdv.16751. Epub 2020 Jul 3.
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Chilblain and Acral Purpuric Lesions in Spain during Covid Confinement: Retrospective Analysis of 12 Cases.西班牙新冠疫情封锁期间的冻疮和肢端紫癜性病变：12例回顾性分析
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Going viral: A brief history of Chilblain-like skin lesions ("COVID toes") amidst the COVID-19 pandemic.病毒式传播：COVID-19 大流行期间冻疮样皮肤损伤（“COVID 脚趾”）的简要历史。
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Chilblain-like acral dermatosis.冻疮样肢端皮肤病
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A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection.19 例意大利儿科患者类冻疮样皮损的临床、组织病理学和实验室研究：与 COVID-19 感染关系的明与暗。
J Eur Acad Dermatol Venereol. 2020 Nov;34(11):2620-2629. doi: 10.1111/jdv.16682. Epub 2020 Jul 2.
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Chilblains in children in the setting of COVID-19 pandemic.新冠疫情背景下儿童的冻疮
Pediatr Dermatol. 2020 May;37(3):406-411. doi: 10.1111/pde.14215. Epub 2020 May 22.

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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis.急性 COVID-19 综合征后心血管症状的患病率：一项荟萃分析。
BMC Med. 2025 Feb 6;23(1):70. doi: 10.1186/s12916-025-03908-3.
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Beau's Lines and COVID-19; A Systematic Review on Their Association.博氏线与新型冠状病毒肺炎；关于它们之间关联的系统评价
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Obstet Med. 2023 Dec;16(4):256-259. doi: 10.1177/1753495X221109461. Epub 2022 Jun 19.
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Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic.定义 COVID-19 的短期和长期皮肤表现：大流行三年多后的洞察。
Rom J Morphol Embryol. 2023 Jul-Sep;64(3):291-304. doi: 10.47162/RJME.64.3.01.
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Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies.长期新冠：并发症、潜在机制及治疗策略
Arch Microbiol Immunol. 2023;7(2):36-61. Epub 2023 May 9.
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Post-COVID-19 Syndrome Mechanisms, Prevention and Management.新冠后综合征的机制、预防与管理。
Int J Prev Med. 2023 May 24;14:59. doi: 10.4103/ijpvm.ijpvm_508_21. eCollection 2023.
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Low avidity circulating SARS-CoV-2 reactive CD8+ T cells with proinflammatory TEMRA phenotype are associated with post-acute sequelae of COVID-19.具有促炎TEMRA表型的低亲和力循环严重急性呼吸综合征冠状病毒2反应性CD8+T细胞与冠状病毒病的急性后遗症相关。
Front Microbiol. 2023 Jun 2;14:1196721. doi: 10.3389/fmicb.2023.1196721. eCollection 2023.
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Follow-Up of a Cohort of Patients with Post-Acute COVID-19 Syndrome in a Belgian Family Practice.对一家比利时家庭诊所中患有新冠后综合征的患者队列进行随访。
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The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implications.缺血再灌注损伤在类风湿性关节炎、长新冠和 ME/CFS 等慢性、复发性疾病中的潜在作用：证据、机制和治疗意义。
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本文引用的文献

1
Long COVID in the skin: a registry analysis of COVID-19 dermatological duration.皮肤领域的新冠后综合征：一项关于新冠病毒感染皮肤病持续时间的登记分析。
Lancet Infect Dis. 2021 Mar;21(3):313-314. doi: 10.1016/S1473-3099(20)30986-5. Epub 2021 Jan 15.
2
Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement.新冠肺炎患者甲襞毛细血管显微镜检查结果：拓宽 COVID-19 微血管受累谱。
Microvasc Res. 2021 Jan;133:104071. doi: 10.1016/j.mvr.2020.104071. Epub 2020 Sep 17.
3
A clinical, histopathological and laboratory study of 19 consecutive Italian paediatric patients with chilblain-like lesions: lights and shadows on the relationship with COVID-19 infection.19 例意大利儿科患者类冻疮样皮损的临床、组织病理学和实验室研究：与 COVID-19 感染关系的明与暗。
J Eur Acad Dermatol Venereol. 2020 Nov;34(11):2620-2629. doi: 10.1111/jdv.16682. Epub 2020 Jul 2.
4
BSR and BHPR guideline for the treatment of systemic sclerosis.英国风湿病学会和英国卫生与保健改善署系统性硬化症治疗指南
Rheumatology (Oxford). 2016 Oct;55(10):1906-10. doi: 10.1093/rheumatology/kew224. Epub 2016 Jun 9.
5
Consensus best practice pathway of the UK Scleroderma Study Group: digital vasculopathy in systemic sclerosis.英国硬皮病研究组的共识最佳实践路径：系统性硬化症的数字血管病变。
Rheumatology (Oxford). 2015 Nov;54(11):2015-24. doi: 10.1093/rheumatology/kev201. Epub 2015 Jun 26.

Chilblain-like acral lesions in long COVID-19: management and implications for understanding microangiopathy.

作者信息

Mehta Puja, Bunker Christopher B, Ciurtin Coziana, Porter Joanna C, Chambers Rachel C, Papdopoulou Charalampia, Garthwaite Helen, Hillman Toby, Heightman Melissa, Howell Kevin J, Eleftheriou Despina, Denton Christopher P

机构信息

Centre for Inflammation and Tissue Repair, University College London (UCL) Respiratory, Division of Medicine, UCL, London, UK; Department of Rheumatology, UCL Hospital, London, UK.

Department of Dermatology, UCL Hospital, London, UK.

出版信息

Lancet Infect Dis. 2021 Jul;21(7):912. doi: 10.1016/S1473-3099(21)00133-X. Epub 2021 Mar 8.

DOI:10.1016/S1473-3099(21)00133-X
PMID:33705725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8221732/
Abstract
摘要