Brey P T, Lebrun R A, Papierok B, Ohayon H, Vennavalli S, Hafez J
Unité de Lutte biologique contre les Insectes, Institut Pasteur, Paris, France.
Cell Tissue Res. 1988 Jul;253(1):245-50. doi: 10.1007/BF00221760.
The adherence of zoospores of Lagenidium giganteum to the cuticle of mosquito larvae is the initial step in the infection process. Subsequently, a germ tube penetrates the integument, inducing a rapid melanization of the injured cuticle and epidermis. After entering the hemocoel the developing hyphae are occasionally encapsulated locally. This process is slow (6 to 12 h postincubation) and most frequently cell-free, although it can be mediated by circulating hemocytes. Sporadic hemocyte mediation of the humoral encapsulation process in larval stages of Culicidae adds a previously unreported dimension to this unusual type of defense reaction. The defense reactions of larvae of Aedes aegypti were ineffective against observed infection by Lagenidium giganteum.
巨大拉格孢菌游动孢子附着于蚊虫幼虫的表皮是感染过程的起始步骤。随后，一根芽管穿透体壁，致使受伤的表皮和真皮迅速黑化。进入血腔后，发育中的菌丝偶尔会在局部被包囊化。这个过程较为缓慢（孵育后6至12小时），且大多时候是无细胞参与的，不过它也可由循环血细胞介导。在蚊科幼虫阶段，体液包囊化过程中偶尔出现的血细胞介导作用，为这种不同寻常的防御反应增添了一个此前未被报道的层面。埃及伊蚊幼虫的防御反应对于观察到的巨大拉格孢菌感染并无效果。
