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用于癌症免疫治疗的智能刺激响应纳米免疫调节剂

Intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy.

作者信息

Li Yanhua, Zhang Xia, Liu Xiaohan, Pan Wei, Li Na, Tang Bo

机构信息

College of Chemistry, Chemical Engineering and Materials Science Key Laboratory of Molecular and Nano Probes, Ministry of Education Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University Jinan 250014 P. R. China

出版信息

Chem Sci. 2021 Feb 10;12(9):3130-3145. doi: 10.1039/d0sc06557a.

DOI:10.1039/d0sc06557a
PMID:34164080
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8179382/
Abstract

Cancer immunotherapy is a revolutionary treatment method in oncology, which uses a human's own immune system against cancer. Many immunomodulators that trigger an immune response have been developed and applied in cancer immunotherapy. However, there is the risk of causing an excessive immune response upon directly injecting common immunomodulators into the human body to trigger an immune response. Therefore, the development of intelligent stimuli-responsive immunomodulators to elicit controlled immune responses in cancer immunotherapy is of great significance. Nanotechnology offers the possibility of designing smart nanomedicine to amplify the antitumor response in a safe and effective manner. Progress relating to intelligent stimuli-responsive nano immunomodulators for cancer immunotherapy is highlighted as a new creative direction in the field. Considering the clinical demand for cancer immunotherapy, we put forward some suggestions for constructing new intelligent stimuli-responsive nano immunomodulators, which will advance the development of cancer immunotherapy.

摘要

癌症免疫疗法是肿瘤学中一种革命性的治疗方法，它利用人体自身的免疫系统对抗癌症。许多能够引发免疫反应的免疫调节剂已被研发出来并应用于癌症免疫疗法。然而，将普通免疫调节剂直接注入人体以引发免疫反应时，存在引起过度免疫反应的风险。因此，开发智能刺激响应型免疫调节剂以在癌症免疫疗法中引发可控的免疫反应具有重要意义。纳米技术为设计智能纳米药物以安全有效地增强抗肿瘤反应提供了可能性。用于癌症免疫疗法的智能刺激响应型纳米免疫调节剂方面的进展被视为该领域一个新的创新方向。考虑到癌症免疫疗法的临床需求，我们对构建新型智能刺激响应型纳米免疫调节剂提出了一些建议，这将推动癌症免疫疗法的发展。

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