Brosset B, Myara I, Fabre M, Lemonnier A
Laboratoire de Biochimie, CHU Bicetre, Le Kremlin-Bicetre, France.
Clin Chim Acta. 1988 Jul 29;175(3):291-5. doi: 10.1016/0009-8981(88)90105-2.
Prolidase (EC 3.4.13.9) and prolinase (EC 3.4.13.8) activity was measured in the plasma of 53 patients with alcoholic liver disease. Plasma prolinase activity was not correlated with histological characteristics in liver biopsies. In contrast, prolidase activity rose significantly (p less than 0.02) in cirrhotic patients with alcoholic hepatitis in comparison with those without alcoholic hepatitis. It also showed a significant positive correlation with ASAT activity (r = 0.505, p less than 0.001) and with the ASAT/ALAT ratio (r = 0.452, p less than 0.001). Plasma prolidase activity did not allow the differentiation of patients with reversible fibrosis from those with cirrhosis. The interest of this new marker is discussed.
在53例酒精性肝病患者的血浆中测定了脯氨酰二肽氨基肽酶（EC 3.4.13.9）和脯氨酸酶（EC 3.4.13.8）的活性。血浆脯氨酸酶活性与肝活检的组织学特征无关。相比之下，与无酒精性肝炎的肝硬化患者相比，酒精性肝炎肝硬化患者的脯氨酰二肽氨基肽酶活性显著升高（p<0.02）。它还与谷草转氨酶活性呈显著正相关（r = 0.505，p<0.001），与谷草转氨酶/谷丙转氨酶比值呈显著正相关（r = 0.452，p<0.001）。血浆脯氨酰二肽氨基肽酶活性无法区分可逆性纤维化患者和肝硬化患者。本文讨论了这一新标志物的意义。
