Influence of hypothermia on the generalized Shwartzman reaction.

In normothermic rabbits the generalized Shwartzman reaction can usually be elicited by two intravenous injections of endotoxin spaced 24 hr apart. The reaction could be prevented by cooling the rabbits. Hypothermia is effective only at the time of the second injection. The protective effect can clearly be demonstrated by gross and histologic examination. The possible mechanism of the protective action of hypothermia is discussed.