Rische H, Tschäpe H, Witte W
Acta Microbiol Acad Sci Hung. 1977;24(3):253-60.
The surveillance of R-plasmids consists of: (1.) Ecological and epidemiological investigations. (1.1.) Prevalence of R-plasmids in pathogenic and apathogenic bacteria occurring in the biotic environment (man, animal); in the abiotic environment (sewage, food, feed); under high selection pressure (hospital, animal production, plant production). (2.) Biological investigations. (2.1.) Genetic properties of R-plasmids: (2.2.) Plasmid induced variations of the properties of the host bacteria (virulence, phage pattern, antigenic pattern, serological properties). The problems resulting from plasmid-mediated drug resistance call for a strict chemotherapeutic drug policy with the regard to ecological processes.
R质粒的监测包括：（1）生态学和流行病学调查。（1.1）R质粒在生物环境（人类、动物）中出现的致病和非致病细菌中的流行情况；在非生物环境（污水、食物、饲料）中的流行情况；在高选择压力下（医院、动物生产、植物生产）的流行情况。（2）生物学调查。（2.1）R质粒的遗传特性：（2.2）质粒诱导的宿主细菌特性变化（毒力、噬菌体模式、抗原模式、血清学特性）。质粒介导的耐药性所引发的问题要求在生态过程方面制定严格的化疗药物政策。
