Department of Public health, Occupational and Environmental Medicine, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
J Prim Care Community Health. 2021 Jan-Dec;12:21501327211027432. doi: 10.1177/21501327211027432.
This study aimed to evaluate the interleukin-6 (IL-6) levels and its relationship to stress, anxiety, and depressive symptoms among healthcare workers (HCWs) compared to controls during the COVID-19 pandemic.
A total of 80 HCWs in Suez Canal University Hospital in Ismailia, Egypt, and 80 controls were analyzed during the COVID-19 pandemic. The Depression, Anxiety and Stress Scale (DASS 21) questionnaire was used, and serum IL-6 level was determined in both groups.
IL-6 levels were high in 81.2% (65) of HCWs compared to 36% (45) of controls ( < .05). The DASS score was higher in participants with high IL-6 levels (>3 ng/mL) than in those with mild to moderate levels ( < .05). The regression model revealed that the type of work as a healthcare staff, irregular or night shift, and stress were predictors of increased IL-6 levels among the studied sample ( < .05) (odds ratio = 20.30, 2.44, and 2.04, respectively).
The IL-6 level and DASS score were higher in HCWs compared to those in controls during the COVID-19 pandemic. The type of work as a healthcare staff, stress, and irregular or night shift were predictors of increased IL-6 levels.
本研究旨在评估白细胞介素 6（IL-6）水平及其与压力、焦虑和抑郁症状在 COVID-19 大流行期间医护人员（HCWs）与对照组之间的关系。
在 COVID-19 大流行期间，对埃及伊斯梅里亚苏伊士运河大学医院的 80 名 HCWs 和 80 名对照组进行了分析。使用抑郁、焦虑和压力量表（DASS 21）问卷，并确定了两组的血清 IL-6 水平。
与对照组的 36%（45 名）相比，81.2%（65 名）的 HCWs 的 IL-6 水平较高（<0.05）。与 IL-6 水平轻度至中度（<0.05）相比，IL-6 水平较高（>3ng/mL）的参与者的 DASS 评分更高。回归模型显示，作为医护人员的工作类型、不规律或夜班以及压力是研究样本中 IL-6 水平升高的预测因素（<0.05）（比值比分别为 20.30、2.44 和 2.04）。
与 COVID-19 大流行期间的对照组相比，HCWs 的 IL-6 水平和 DASS 评分更高。作为医护人员的工作类型、压力和不规律或夜班是 IL-6 水平升高的预测因素。
