Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Eur Heart J Cardiovasc Imaging. 2022 Jun 1;23(6):855-862. doi: 10.1093/ehjci/jeab122.
The role of atherosclerosis in the pathogenesis of aortic enlargement is uncertain. We aimed to evaluate the relationship between the diameters of the ascending, descending and abdominal aorta, and coronary artery calcification.
Individuals in the Copenhagen General Population Study underwent thoracic and abdominal computed tomography. Maximal aortic diameters were measured in each aortic segment and coronary artery calcium scores (CACS) were calculated. Participants were stratified into five predefined groups according to CACSs and compared to aortic dimensions. The relation between aortic diameter and CACS was adjusted for risk factors for aortic dilatation in a multivariable model. A total of 2678 eligible individuals were included. In all segments of the aorta, aortic diameter was associated to CACSs, with mean increases in aortic diameters ranging from 0.7 to 3.5 mm in individuals with calcified coronary arteries compared to non-calcified subjects (P-value < 0.001). After correction for risk factors, individuals with CACS above 400 had larger ascending, descending and abdominal aortic diameter than the non-calcified reference group (P-value < 0.01).
Enlarged thoracic and abdominal aortic vascular segments are associated with co-existing coronary artery calcification in the general population.
动脉粥样硬化在主动脉扩张发病机制中的作用尚不确定。本研究旨在评估升主动脉、降主动脉和腹主动脉直径与冠状动脉钙化之间的关系。
哥本哈根普通人群研究中的个体接受了胸部和腹部计算机断层扫描。在每个主动脉节段测量最大主动脉直径，并计算冠状动脉钙评分（CACS）。根据 CACS 将参与者分为五个预定组，并与主动脉尺寸进行比较。在多变量模型中，将主动脉直径与 CACS 的关系调整为主动脉扩张的危险因素。共纳入 2678 名符合条件的个体。在主动脉的所有节段中，主动脉直径与 CACS 相关，与无钙化的受试者相比，有钙化冠状动脉的个体的主动脉直径平均增加 0.7 至 3.5 毫米（P 值 < 0.001）。校正危险因素后，CACS 高于 400 的个体的升主动脉、降主动脉和腹主动脉直径大于无钙化的参考组（P 值 < 0.01）。
在普通人群中，增大的胸主动脉和腹主动脉血管节段与同时存在的冠状动脉钙化有关。
