Liu F S, Rubio C A
Cancer Institute, Chinese Academy of Medical Sciences, Beijing.
Zhonghua Zhong Liu Za Zhi. 1988 Jan;10(1):26-8.
DNA distribution of 4 early esophageal cancers and their epithelial adjacent to cancer was analysed using photocytometry technique. In the tissues around the cancer, DNA content of the normal squamous epithelium always showed diploid (2 c) or proliferating diploid (less than 5 c). DNA content of 3 cases of the dysplastic cells in three specimens was predominantly proliferating diploid, comprising 68%, 38.2% and 59.4% but the aneuploid (greater than 5 c), 8%, 2.9% and 21.8%, respectively. In 4 cases of carcinoma in situ, the aneuploid increased to 86.7%, 68.7%, 17.2% and 28.6%, markedly higher than the dysplastic cells. In 3 cases of early esophageal cancer, the aneuploid accounted for 58.8%, 51.1% and 13.6%, similar to carcinoma in situ. The results indicate that in the dysplastic cells, there is a relative high ratio of the aneuploid cells except the increased proliferating diploid. This phenomenon could explain the unstability for dysplasia and might be the earliest manifestation of malignant change of the epithelial cells.
采用细胞光度测定技术分析了4例早期食管癌及其癌旁上皮组织的DNA分布情况。在癌周组织中，正常鳞状上皮的DNA含量始终显示为二倍体（2c）或增殖二倍体（小于5c）。三个标本中3例发育异常细胞的DNA含量主要为增殖二倍体，分别占68%、38.2%和59.4%，而异倍体（大于5c）分别占8%、2.9%和21.8%。在4例原位癌中，异倍体分别增至86.7%、68.7%、17.2%和28.6%，明显高于发育异常细胞。在3例早期食管癌中，异倍体分别占58.8%、51.1%和13.6%，与原位癌相似。结果表明，在发育异常细胞中，除增殖二倍体增加外，异倍体细胞的比例相对较高。这种现象可以解释发育异常的不稳定性，可能是上皮细胞恶性变的最早表现。
