Zhao Q N, Zhou Y M, Sun C Y
Department of Plastic and Reconstructive Surgery, Huaihe Hospital, Henan University, Kaifeng 475000, China.
Zhonghua Shao Shang Za Zhi. 2021 Jun 20;37(6):586-590. doi: 10.3760/cma.j.cn501120-20200315-00167.
Traumatic scar can not only exert influence on appearance and function of patients, but also affect psychological health status and life quality of patients to varying degrees. At present, scholars have confirmed from basic research that mechanical tension promotes the proliferation of inflammatory cells, fibroblasts, and other cells, as well as angiogenesis and epithelialization through a variety of mechanical conduction pathways and plays an important role in the formation of hypertrophic scar. Clinical studies have confirmed that surgical methods and adjuvant treatment to reduce the mechanical tension on wound can promote wound healing and inhibit hyperplasia of scar. This article summarizes the mechanism of hypertrophic scar formation, and surgical methods and adjunct means of reducing mechanical tension in traumatic wounds, aiming to provide a reference for reducing formation of hypertrophic scar in clinics.
创伤性瘢痕不仅会对患者的外观和功能产生影响，还会在不同程度上影响患者的心理健康状况和生活质量。目前，学者们已从基础研究中证实，机械张力通过多种机械传导途径促进炎性细胞、成纤维细胞等细胞的增殖，以及血管生成和上皮形成，在增生性瘢痕的形成中起重要作用。临床研究证实，通过手术方法及辅助治疗以减轻伤口上的机械张力，可促进伤口愈合并抑制瘢痕增生。本文综述了增生性瘢痕的形成机制，以及减轻创伤性伤口机械张力的手术方法和辅助手段，旨在为临床减少增生性瘢痕的形成提供参考。
