Lei J A, Zhou Y, Qin Z L
Department of Plastic Surgery,Peking University Third Hospital, Beijing 100191, China.
Zhonghua Shao Shang Za Zhi. 2021 Jun 20;37(6):591-595. doi: 10.3760/cma.j.cn501120-20200312-00154.
Keloid is a hyperplastic pathological scar of body caused by infection, trauma, and surgery or formed spontaneously for unknown reasons. It is an excessive tissue response of body to dermal injury. The paper introduces the research advances on inflammatory responses involved in keloid development and keloid treatment by inhibiting inflammatory responses from the aspects of inflammation inducing factors, inflammatory cells, inflammatory mediators, inflammatory effectors, and influencing factors of inflammatory responses. The research results suggest that inflammatory responses are not only essential process to normal wound healing, but also key factors on keloid formation and development.
瘢痕疙瘩是由感染、创伤、手术引起的身体增生性病理性瘢痕，或原因不明自发形成。它是身体对真皮损伤的过度组织反应。本文从炎症诱导因子、炎症细胞、炎症介质、炎症效应器以及炎症反应影响因素等方面介绍了瘢痕疙瘩形成过程中炎症反应的研究进展以及通过抑制炎症反应治疗瘢痕疙瘩的研究情况。研究结果表明，炎症反应不仅是正常伤口愈合的必要过程，也是瘢痕疙瘩形成和发展的关键因素。
