[瘢痕疙瘩形成过程中炎症反应的研究进展]
[Research advances on inflammatory responses involved in keloid development].
作者信息
Lei J A, Zhou Y, Qin Z L
机构信息
Department of Plastic Surgery,Peking University Third Hospital, Beijing 100191, China.
出版信息
Zhonghua Shao Shang Za Zhi. 2021 Jun 20;37(6):591-595. doi: 10.3760/cma.j.cn501120-20200312-00154.
Abstract
Keloid is a hyperplastic pathological scar of body caused by infection, trauma, and surgery or formed spontaneously for unknown reasons. It is an excessive tissue response of body to dermal injury. The paper introduces the research advances on inflammatory responses involved in keloid development and keloid treatment by inhibiting inflammatory responses from the aspects of inflammation inducing factors, inflammatory cells, inflammatory mediators, inflammatory effectors, and influencing factors of inflammatory responses. The research results suggest that inflammatory responses are not only essential process to normal wound healing, but also key factors on keloid formation and development.
摘要
瘢痕疙瘩是由感染、创伤、手术引起的身体增生性病理性瘢痕，或原因不明自发形成。它是身体对真皮损伤的过度组织反应。本文从炎症诱导因子、炎症细胞、炎症介质、炎症效应器以及炎症反应影响因素等方面介绍了瘢痕疙瘩形成过程中炎症反应的研究进展以及通过抑制炎症反应治疗瘢痕疙瘩的研究情况。研究结果表明，炎症反应不仅是正常伤口愈合的必要过程，也是瘢痕疙瘩形成和发展的关键因素。
相似文献
1
[Research advances on inflammatory responses involved in keloid development].[瘢痕疙瘩形成过程中炎症反应的研究进展]
Zhonghua Shao Shang Za Zhi. 2021 Jun 20;37(6):591-595. doi: 10.3760/cma.j.cn501120-20200312-00154.
2
The Roles of Inflammation in Keloid and Hypertrophic Scars.炎症在瘢痕疙瘩和增生性瘢痕中的作用。
Front Immunol. 2020 Dec 4;11:603187. doi: 10.3389/fimmu.2020.603187. eCollection 2020.
3
Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.内皮功能障碍可能在瘢痕疙瘩和增生性瘢痕的发病机制中起关键作用——瘢痕疙瘩和增生性瘢痕可能是血管性疾病。
Med Hypotheses. 2016 Nov;96:51-60. doi: 10.1016/j.mehy.2016.09.024. Epub 2016 Sep 28.
4
Regulation of glycolysis and the Warburg effect in wound healing.创伤愈合中糖酵解和瓦博格效应的调控。
JCI Insight. 2020 Sep 3;5(17):138949. doi: 10.1172/jci.insight.138949.
5
Controlling Inflammation Pre-Emptively or at the Time of Cutaneous Injury Optimises Outcome of Skin Scarring.预先控制炎症或在皮肤损伤时进行控制，可优化皮肤瘢痕的转归。
Front Immunol. 2022 May 27;13:883239. doi: 10.3389/fimmu.2022.883239. eCollection 2022.
6
Pathogenesis, attenuation, and treatment strategies for keloid management.
Tissue Cell. 2025 Jun;94:102800. doi: 10.1016/j.tice.2025.102800. Epub 2025 Feb 17.
7
Keloids: current concepts of pathogenesis (review).瘢痕疙瘩：发病机制的当前概念（综述）
Int J Mol Med. 2009 Sep;24(3):283-93. doi: 10.3892/ijmm_00000231.
8
Drug delivery to optimize angiogenesis imbalance in keloid: A review.药物输送优化瘢痕疙瘩中的血管生成失衡：综述。
J Control Release. 2021 Jan 10;329:1066-1076. doi: 10.1016/j.jconrel.2020.10.035. Epub 2020 Oct 20.
9
[Advances in the research of the effect of toll-like receptor in the formation of keloid].
Zhonghua Shao Shang Za Zhi. 2013 Aug;29(4):378-81.
10
Inflammation in Wound Healing and Pathological Scarring.伤口愈合与病理性瘢痕形成中的炎症
Adv Wound Care (New Rochelle). 2023 May;12(5):288-300. doi: 10.1089/wound.2021.0161.
引用本文的文献
1
Expression of macrophage activation‑specific factors in hyperplastic scar tissue during hyperplasia phase by antibody array blotting membrane assay and its clinical significance.抗体芯片印迹膜法检测增生期增生性瘢痕组织中巨噬细胞活化特异性因子的表达及其临床意义
Exp Ther Med. 2024 Jan 29;27(3):116. doi: 10.3892/etm.2024.12403. eCollection 2024 Mar.
2
Effect of Mortalin on Scar Formation in Human Dermal Fibroblasts and a Rat Incisional Scar Model.衰老相关蛋白 Mortalin 对人真皮成纤维细胞瘢痕形成及大鼠切口瘢痕模型的影响。
Int J Mol Sci. 2022 Jul 18;23(14):7918. doi: 10.3390/ijms23147918.
本文引用的文献
1
Understanding Keloid Pathobiology From a Quasi-Neoplastic Perspective: Less of a Scar and More of a Chronic Inflammatory Disease With Cancer-Like Tendencies.从类肿瘤角度理解瘢痕疙瘩的病理生物学：不只是瘢痕，更是一种具有癌症倾向的慢性炎症性疾病。
Front Immunol. 2019 Aug 7;10:1810. doi: 10.3389/fimmu.2019.01810. eCollection 2019.
2
The Interplay of Mechanical Stress, Strain, and Stiffness at the Keloid Periphery Correlates with Increased Caveolin-1/ROCK Signaling and Scar Progression.瘢痕瘤周边机械应力、应变和僵硬的相互作用与窖蛋白-1/ROCK 信号的增加和瘢痕进展有关。
Plast Reconstr Surg. 2019 Jul;144(1):58e-67e. doi: 10.1097/PRS.0000000000005717.
3
Regeneration of Dermis: Scarring and Cells Involved.皮肤组织再生：疤痕和涉及的细胞。
Cells. 2019 Jun 18;8(6):607. doi: 10.3390/cells8060607.
4
Efficacy of surgical excision and sub-dermal injection of triamcinolone acetonide for treatment of keloid scars after caesarean section: a single blind randomised controlled trial protocol.手术切除联合曲安奈德皮下注射治疗剖宫产术后瘢痕疙瘩的疗效：一项单盲随机对照试验方案。
Trials. 2019 Jun 18;20(1):363. doi: 10.1186/s13063-019-3465-6.
5
Immune- and non-immune-mediated roles of regulatory T-cells during wound healing.调节性 T 细胞在创伤愈合过程中的免疫和非免疫介导作用。
Immunology. 2019 Jul;157(3):190-197. doi: 10.1111/imm.13057. Epub 2019 Apr 9.
6
Skin-Associated B Cells in Health and Inflammation.皮肤相关 B 细胞在健康与炎症中的作用
J Immunol. 2019 Mar 15;202(6):1659-1666. doi: 10.4049/jimmunol.1801211.
7
5-HT1A Receptor Function Makes Wound Healing a Happier Process.5-羟色胺1A受体功能使伤口愈合成为一个更顺利的过程。
Front Pharmacol. 2018 Dec 11;9:1406. doi: 10.3389/fphar.2018.01406. eCollection 2018.
8
Wound Healing: A Cellular Perspective.创伤愈合：细胞视角。
Physiol Rev. 2019 Jan 1;99(1):665-706. doi: 10.1152/physrev.00067.2017.
9
Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.皮肤伤口愈合的免疫调节：机制与新型治疗靶点
Adv Wound Care (New Rochelle). 2018 Jul 1;7(7):209-231. doi: 10.1089/wound.2017.0761.
10
Revisiting IL-2: Biology and therapeutic prospects.重新审视白细胞介素-2：生物学和治疗前景。
Sci Immunol. 2018 Jul 6;3(25). doi: 10.1126/sciimmunol.aat1482.
Zotero 插件