Department of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107
Department of Microbiology and Immunology, Sidney Kimmel Medical College, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107.
J Immunol. 2019 Mar 15;202(6):1659-1666. doi: 10.4049/jimmunol.1801211.
Traditionally, the skin was believed to be devoid of B cells, and studies of the skin immune system have largely focused on other types of leukocytes. Exciting recent data show that B cells localize to the healthy skin of humans and other mammalian species with likely homeostatic functions in host defense, regulation of microbial communities, and wound healing. Distinct skin-associated B cell subsets drive or suppress cutaneous inflammatory responses with important clinical implications. Localized functions of skin-associated B cell subsets during inflammation comprise Ab production, interactions with skin T cells, tertiary lymphoid tissue formation, and production of proinflammatory cytokines but also include immunosuppression by providing IL-10. In this review, we delve into the intriguing new roles of skin-associated B cells in homeostasis and inflammation.
传统上，皮肤被认为缺乏 B 细胞，而皮肤免疫系统的研究主要集中在其他类型的白细胞上。最近令人兴奋的数据表明，B 细胞定位于人类和其他哺乳动物的健康皮肤中，可能具有宿主防御、调节微生物群落和伤口愈合的稳态功能。不同的皮肤相关 B 细胞亚群驱动或抑制皮肤炎症反应，具有重要的临床意义。皮肤相关 B 细胞亚群在炎症过程中的局部功能包括产生 Ab、与皮肤 T 细胞相互作用、形成三级淋巴组织和产生促炎细胞因子，但也包括通过提供 IL-10 来抑制免疫。在这篇综述中，我们深入探讨了皮肤相关 B 细胞在稳态和炎症中的这些令人着迷的新作用。
